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DNASE1L1 - deoxyribonuclease 1 like 1 Gene

Also Known as XIB; G4.8; DNL1L; DNASEX; DNAS1L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1774

About DNASE1L1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,401,236-154,412,101 (from NCBI)

This gene has 12 transcripts (splice variants), 228 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 6.9), heart (RPKM 6.8) and 25 other tissues.

Summary

This gene encodes a deoxyribonuclease protein that shows high sequence similarity to DNase I. The encoded protein is localized to the endoplasmic reticulum and modified by N-linked glycosylation. Alternate transcriptional splice variants encoding the same protein have been observed. [provided by RefSeq, Jan 2015]

DNASE1L1 Products (5)

mRNA	Protein	Name
NM_001009932.3	NP_001009932.1	deoxyribonuclease-1-like 1 precursor
NM_001009933.3	NP_001009933.1	deoxyribonuclease-1-like 1 precursor
NM_001009934.3	NP_001009934.1	deoxyribonuclease-1-like 1 precursor
NM_001303620.2	NP_001290549.1	deoxyribonuclease-1-like 1 precursor
NM_006730.4	NP_006721.1	deoxyribonuclease-1-like 1 precursor

DNASE1L1 Protein Structure

Exo_endo_phos

0
100
200
302 a.a.

Protein Preferred Names	Protein Names
deoxyribonuclease-1-like 1	DNase I, lysosomal-like

DNASE1L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DNASE1L1	P49184	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	DNASE1L1	P49184	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	DNASE1L1	P49184	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	DNASE1L1	P49184	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	DNASE1L1	P49184	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	DNASE1L1	P49184	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	DNASE1L1	P49184	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	DNASE1L1	P49184	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	DNASE1L1	P49184	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	DNASE1L1	P49184	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
Intra	DNASE1L1	P49184	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
Intra	DNASE1L1	P49184	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
Intra	DNASE1L1	P49184	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
Intra	DNASE1L1	P49184	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	DNASE1L1	P49184	DLST	Homo sapiens	P36957	Y2H Array	32814053
Intra	DNASE1L1	P49184	HSPA5	Homo sapiens	P11021	Crosslink	30021884
Intra	DNASE1L1	P49184	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	33961781
Intra	DNASE1L1	P49184	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	DNASE1L1	P49184	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	DNASE1L1	P49184	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	DNASE1L1	P49184	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	DNASE1L1	P49184	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	DNASE1L1	P49184	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	DNASE1L1	P49184	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
Intra	DNASE1L1	P49184	CDH1	Homo sapiens	P12830	Y2H Array	32814053
Intra	DNASE1L1	P49184	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
Intra	DNASE1L1	P49184	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	DNASE1L1	P49184	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	DNASE1L1	P49184	GRN	Homo sapiens	P28799	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Barth Syndrome	3-Methylglutaconic Aciduria Type 2 BTHS Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria Mga Type Ii Mga2 Mgca2 Mga Type 2 3-Methylglutaconic Aciduria Type Ii 3-Methylglutaconic Aciduria, Type Ii Mga, Type Ii 3-Methylglutaconicaciduria Type 2 3-Methylglutaconicaciduria Type Ii Taz Defect 3 Methylglutaconic Aciduria, Type Ii Dnajc19 Defect Cardioskeletal Myopathy-Neutropenia Syndrome X-Linked Cardioskeletal Myopathy And Neutropenia 3-Alpha-Methylglutaconic Aciduria Type 2 Agm2 Cardioskeletal Myopathy-Neutropenia Invm Left Ventricular Non-Compaction Isolated X-Linked Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked Agammaglobulinemia 2, Autosomal Recessive
Human Monocytic Ehrlichiosis	Ehrlichiosis Chafeensis Hme Human Ehrlichial Infection, Human Monocytic Type
Chronic Follicular Conjunctivitis
Ehrlichiosis	Human Ehrlichiosis He Hey
Glycogen Storage Disease Ii	Pompe Disease Glycogen Storage Disease Type Ii Acid Maltase Deficiency Gsd Ii Gaa Deficiency Alpha-1,4-Glucosidase Deficiency Glycogenosis Type Ii GSD2 Acid Alpha-Glucosidase Deficiency Amd Glycogen Storage Disease, Type Ii Pompe'S Disease Glycogen Storage Disease Type 2 Cardiomegalia Glycogenica Diffusa Acid Maltase Deficiency Disease Deficiency Of Alpha-Glucosidase Glycogenosis, Generalized, Cardiac Form Deficiency Of Glucoamylase Deficiency Of Maltase Generalized Glycogenosis Glycogenosis, Type 2 Lysosomal Alpha-1,4-Glucosidase Deficiency Glucosidase Acid-1,4-Alpha Deficiency Aglucosidase Alfa Deficiency Of Lysosomal Alpha-Glucosidase Glycogen Storage Disease Due To Acid Maltase Deficiency Alpha-1,4-Glucosidase Acid Deficiency Gsd Due To Acid Maltase Deficiency Gsd Type 2 Gsd Type Ii Glycogenosis Due To Acid Maltase Deficiency Glycogenosis Type 2 Glycogen Storage Disease 2 Cardiomegalia Glycogenica Glycogenosis Generalized Cardiac Form Glycogenosis Ii Gsd-Ii Storage Disease, Glycogen, Type Ii Generalized Glycogen Storage Disease Of Infants Cardiac Form Of Generalized Glycogenosis
Human Granulocytic Anaplasmosis	Human Granulocytic Ehrlichiosis Hge Human Ehrlichial Infection, Human Granulocytic Type Human Anaplasmosis Due To Anaplasma Phagocytophilum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03895	DNASE1L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DNASE1L1	MGD	MGI:109628
Bos taurus	DNASE1L1	VGNC	VGNC:28133
Canis familiaris	DNASE1L1	VGNC	VGNC:40024
Rattus norvegicus	DNASE1L1	RGD	RGD:1359588
Felis catus	DNASE1L1	VGNC	VGNC:61552
Others	DNASE1L1	NCBI