Ppp1r15a - protein phosphatase 1, regulatory subunit 15A Gene

Also Known as Gadd34; Myd116; 9630030H21

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17872

Summary

Enables protein Phosphatase binding activity and protein Phosphatase regulator activity. Involved in several processes, including peptidyl-serine dephosphorylation; regulation of gene expression; and regulation of protein modification process. Acts upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and mitochondrion. Predicted to be part of protein Phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Used to study thalassemia. Orthologous to human PPP1R15A (protein Phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r15a Products (1)

mRNA Protein Name
NM_008654.2 NP_032680.1 protein phosphatase 1 regulatory subunit 15A

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein phosphatase binding IDA
IDA: Inferred from direct assay
11381086 MGI
enables protein phosphatase regulator activity IDA
IDA: Inferred from direct assay
11381086 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within endoplasmic reticulum unfolded protein response IMP
IMP: Inferred from mutant phenotype
15601821 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11381086 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
14635196 MGI
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
14635196 MGI
involved in positive regulation of transcription by RNA polymerase I IDA
IDA: Inferred from direct assay
14635196 MGI
involved in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
IDA: Inferred from direct assay
11381086 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
11381086 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
15601821 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 15A

  • growth arrest and DNA damage-inducible protein GADD34

  • growth arrest and DNA-damage-inducible 34

  • myeloid differentiation primary response gene 116

  • myeloid differentiation primary response protein MyD116

  • protein phosphatase 1, regulatory (inhibitor) sub

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-110365 Icerguastat Carbonate Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111022 Icerguastat Inhibitor 99.93% Yes
HY-18956 (E/Z)-Icerguastat Inhibitor 99.44% Unkown
HY-RS10986 PPP1R15A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-18956B (E/Z)-Icerguastat acetate Inhibitor / Unkown
HY-18956A (E/Z)-Icerguastat hydrochloride Inhibitor / Unkown
HY-RS17569 Ppp1r15a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24029 Ppp1r15a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp1r15a NCBI NCBI:23645