Nbr1 - NBR1, autophagy cargo receptor Gene

Also Known as mKIAA0049

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17966

Summary

Enables mitogen-activated protein kinase binding activity. Involved in negative regulation of osteoblast differentiation; regulation of bone mineralization; and regulation of stress-activated MAPK cascade. Located in late endosome; mitochondrial intermembrane space; and phagophore assembly site. Colocalizes with autophagosome. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human NBR1 (NBR1 Autophagy cargo receptor). [provided by Alliance of Genome Resources, Apr 2022]

Nbr1 Products (4)

mRNA Protein Name
NM_001252220.1 NP_001239149.1 next to BRCA1 gene 1 protein isoform 1
NM_001252222.1 NP_001239151.1 next to BRCA1 gene 1 protein isoform 2
NM_001252223.1 NP_001239152.1 next to BRCA1 gene 1 protein isoform 3
NM_008676.3 NP_032702.1 next to BRCA1 gene 1 protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mitogen-activated protein kinase binding IDA
IDA: Inferred from direct assay
20616007 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19250911 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20616007 MGI
involved in regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
20616007 MGI
involved in regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
20616007 MGI
Cellular Component GO Annotation Evidence References Source
colocalizes with autophagosome IDA
IDA: Inferred from direct assay
20616007 MGI
located in late endosome IDA
IDA: Inferred from direct assay
19250911 MGI
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
25002142 MGI
located in phagophore assembly site IDA
IDA: Inferred from direct assay
21220506 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

next to BRCA1 gene 1 protein

  • membrane component chromosome 17 surface marker 2 homolog

  • neighbor of BRCA1 gene 1 protein

  • next to the Brca1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146130 ATG7-IN-2 Inhibitor 99.32% Unkown
HY-146131 ATG7-IN-3 Inhibitor 99.26% Unkown
HY-RS09061 NBR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17332 Nbr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23787 Nbr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nbr1 NCBI NCBI:4077