Ncoa2 - nuclear receptor coactivator 2 Gene

Also Known as TIF2; Grip1; SRC-2; GRIP-1; KAT13C; NCoA-2; bHLHe75; D1Ertd433e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17978

Summary

Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and nuclear receptor coactivator activity. Involved in circadian regulation of gene expression; locomotor rhythm; and regulation of glucose metabolic process. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; regulation of transcription by RNA polymerase II; and response to progesterone. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa2 Products (2)

mRNA	Protein	Name
NM_001302702.1	NP_001289631.1	nuclear receptor coactivator 2 isoform b
NM_008678.3	NP_032704.2	nuclear receptor coactivator 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24550004	MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24550004	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15001550	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16109736	MGI
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	15072553	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8643509	MGI
enables signaling receptor binding	IDA IDA: Inferred from direct assay	8643509	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	8643509	MGI
enables transcription coactivator activity	IGI IGI: Inferred from genetic interaction	15383530	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to Thyroglobulin triiodothyronine	IDA IDA: Inferred from direct assay	24550004	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24529706	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	24529706	MGI
involved in locomotor rhythm	IMP IMP: Inferred from mutant phenotype	24529706	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8643509	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8643509	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15383530	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12130539	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24571987	MGI
involved in regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	19039140	MGI
involved in regulation of lipid metabolic process	IDA IDA: Inferred from direct assay	31851938	MGI
acts upstream of or within response to progesterone	IMP IMP: Inferred from mutant phenotype	24571987	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	12130539	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	21152046	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear receptor coactivator 2	glucocorticoid receptor interacting protein 1 steroid receptor coactivator 2 transcriptional intermediary factor 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173033	MI-883		99.57%	Unkown
HY-RS09090	NCOA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19721	Ncoa2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26217	Ncoa2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncoa2	NCBI	NCBI:10499