Ndufv1 - NADH:ubiquinone oxidoreductase core subunit V1 Gene

Also Known as CI-51kD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17995

Summary

This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The human ortholog of this protein has been characterized. It has consensus motifs for NADH, flavin mononucleotide, and iron-sulfur binding sites and participates in the oxidation of NADH as part of the dehydrogenase module of complex I. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. [provided by RefSeq, Jun 2013]

Ndufv1 Products (1)

mRNA Protein Name
NM_133666.3 NP_598427.1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NADH dehydrogenase (ubiquinone) activity IDA
IDA: Inferred from direct assay
29915388 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23530063 MGI
Biological Process GO Annotation Evidence References Source
involved in mitochondrial electron transport, NADH to ubiquinone IDA
IDA: Inferred from direct assay
29915388 MGI
Cellular Component GO Annotation Evidence References Source
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
29915388 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

  • NADH dehydrogenase (ubiquinone) flavoprotein 1

  • NADH dehydrogenase flavoprotein 1

  • 24 kDa (FP)

  • NADH-ubiquinone oxidoreductase 51 kDa subunit

  • complex I-51kD

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09165 NDUFV1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20184 Ndufv1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26688 Ndufv1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndufv1 NCBI NCBI:4723