Nfkbib - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Gene

Also Known as IkB; IkBb; ikB-B; IKB-beta; IKappaBbeta; NF-kappa-BIB; I-kappa-B-beta; I(Kappa)B(beta)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18036

Summary

This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as Cytokines and Growth Factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Nfkbib Products (2)

mRNA Protein Name
NM_001306222.1 NP_001293151.1 NF-kappa-B inhibitor beta
NM_010908.5 NP_035038.2 NF-kappa-B inhibitor beta

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12686541 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
20060382 MGI
acts upstream of or within inflammatory response IGI
IGI: Inferred from genetic interaction
25220458 MGI
acts upstream of or within regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
25220458 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NF-kappa-B inhibitor beta

  • nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09261 NFKBIB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20185 Nfkbib Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26689 Nfkbib Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkbib NCBI NCBI:4793