Nr1i2 - nuclear receptor subfamily 1, group I, member 2 Gene

Also Known as PXR; SXR; PXR1; mPXR; PXR.1; PXR.2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18171

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor binding activity. Acts upstream of or within positive regulation of gene expression. Predicted to be located in intermediate filament Cytoskeleton and nuclear body. Is expressed in several structures, including branchial arch; ear; genitourinary system; heart; and nervous system. Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr1i2 Products (2)

mRNA Protein Name
NM_001098404.1 NP_001091874.1 nuclear receptor subfamily 1 group I member 2 isoform 2
NM_010936.3 NP_035066.1 nuclear receptor subfamily 1 group I member 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11891224 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18794335 MGI
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex EXP
EXP: Inferred from Experiment
17215127 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 1 group I member 2

  • Pregnane X receptor

  • orphan nuclear receptor PXR

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09534 NR1I2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22685 Nr1i2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29199 Nr1i2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr1i2 NCBI NCBI:8856