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Ntrk2 - neurotrophic tyrosine kinase, receptor, type 2 Gene

Also Known as Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18212

About Ntrk2

Chromosome 13: 58,954,383-59,281,784 forward strand.GRCm39:CM001006.3

This gene has 10 transcripts (splice variants), 288 orthologues, 53 paralogues and is associated with 103 phenotypes. Biased expression in frontal lobe adult (RPKM 1.3), cortex adult (RPKM 1.2) and 12 other tissues.

Summary

Enables brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; nervous system development; and trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including neurogenesis; neuronal action potential propagation; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including early endosome; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; future brain; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk2 Products (3)

mRNA	Protein	Name
NM_008745.3	NP_032771.1	BDNF/NT-3 growth factors receptor isoform b precursor
NM_001025074.2	NP_001020245.1	BDNF/NT-3 growth factors receptor isoform a precursor
NM_001282961.1	NP_001269890.1	BDNF/NT-3 growth factors receptor isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables brain-derived neurotrophic factor binding	IDA IDA: Inferred from direct assay	1645620	MGI
enables brain-derived neurotrophic factor receptor activity	IDA IDA: Inferred from direct assay	16801538	MGI
enables neurotrophin binding	IDA IDA: Inferred from direct assay	1645620	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11591653	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in brain-derived neurotrophic factor receptor signaling pathway	IDA IDA: Inferred from direct assay	16801538	MGI
involved in brain-derived neurotrophic factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14603320	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	25542970	MGI
involved in central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	8402890	MGI
involved in cerebral cortex development	IMP IMP: Inferred from mutant phenotype	15372074	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	23785138	MGI
acts upstream of or within feeding behavior	IMP IMP: Inferred from mutant phenotype	12796784	MGI
acts upstream of or within glutamate secretion	IPI IPI: Inferred from physical interaction	16819522	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	10571233	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	12367511	MGI
acts upstream of or within mechanoreceptor differentiation	IMP IMP: Inferred from mutant phenotype	15376326	MGI
acts upstream of or within myelination in peripheral nervous system	IGI IGI: Inferred from genetic interaction	20553714	MGI
involved in negative regulation of anoikis	IDA IDA: Inferred from direct assay	15329723	MGI
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	15372074	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	15372074	MGI
acts upstream of or within neuronal action potential propagation	IGI IGI: Inferred from genetic interaction	20553714	MGI
involved in oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15372074	MGI
acts upstream of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23878391	MGI
involved in peripheral nervous system neuron development	IMP IMP: Inferred from mutant phenotype	8402890	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	12367511	MGI
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	16801538	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23878391	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	24613359	MGI
involved in regulation of GTPase activity	IDA IDA: Inferred from direct assay	16801538	MGI
acts upstream of or within regulation of metabolic process	IMP IMP: Inferred from mutant phenotype	12796784	MGI
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	15372074	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	25542970	MGI
acts upstream of or within retinal rod cell development	IMP IMP: Inferred from mutant phenotype	10516311	MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA IDA: Inferred from direct assay	24991961	MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	24991961	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	16264195	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	11083466	MGI
located in early endosome	IDA IDA: Inferred from direct assay	21849472	MGI
located in endosome	IDA IDA: Inferred from direct assay	24035762	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12646573	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	15601948	MGI
located in terminal bouton	IDA IDA: Inferred from direct assay	16819522	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntrk2 Protein Structure

LRR_8

TPKR_C2

IgI_TrkB_d5

PTKc_TrkB

0
200
400
600
821 a.a.

Protein Preferred Names	Protein Names
BDNF/NT-3 growth factors receptor	neurotrophic tyrosine receptor kinase type 2 trkB tyrosine kinase

Recombinant Ntrk2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72436	TrkB Protein, Mouse (HEK293, His)	P15209-1 (C32-H429)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131003	Taletrectinib	Inhibitor	99.63%	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09631	NTRK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-131003A	Taletrectinib free base	Inhibitor	/	Unkown
HY-101977A	(R,S)-Selitrectinib	Inhibitor	/	Unkown
HY-E70870	TRKB(NTRK2) Recombinant Human Active Protein Kinase		/	Unkown
HY-RS09632	Ntrk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09633	Ntrk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991098	Anti-TrkB/NTRK2 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk2	NCBI	NCBI:4915