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Ntrk3 - neurotrophic tyrosine kinase, receptor, type 3 Gene

Also Known as TrkC; Ntrk3_tv3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18213

About Ntrk3

Chromosome 7: 77,825,707-78,387,760 reverse strand.GRCm39:CM001000.3

This gene has 20 transcripts (splice variants), 271 orthologues, 53 paralogues and is associated with 41 phenotypes. Broad expression in cerebellum adult (RPKM 7.6), CNS E18 (RPKM 6.3) and 16 other tissues.

Summary

Predicted to enable several functions, including GPI-linked Ephrin Receptor activity; neurotrophin binding activity; and p53 binding activity. Acts upstream of or within several processes, including lens fiber cell differentiation; neurogenesis; and neuronal action potential propagation. Located in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and peripheral nervous system. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach Cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk3 Products (2)

mRNA	Protein	Name
NM_008746.5	NP_032772.3	NT-3 growth factor receptor isoform a precursor
NM_182809.2	NP_877961.1	NT-3 growth factor receptor isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11684666	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of axon extension involved in regeneration	IGI IGI: Inferred from genetic interaction	16142215	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	23785138	MGI
acts upstream of or within lens fiber cell differentiation	IGI IGI: Inferred from genetic interaction	23136392	MGI
acts upstream of or within mechanoreceptor differentiation	IMP IMP: Inferred from mutant phenotype	15376326	MGI
acts upstream of or within myelination in peripheral nervous system	IGI IGI: Inferred from genetic interaction	20553714	MGI
acts upstream of or within neuronal action potential propagation	IGI IGI: Inferred from genetic interaction	20553714	MGI
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	23954828	MGI
acts upstream of or within positive regulation of axon extension involved in regeneration	IGI IGI: Inferred from genetic interaction	16142215	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	24613359	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10207144	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntrk3 Protein Structure

LRR_8

LRR_1

TPKR_C2

IgI_TrKABC_d5

PTKc_TrkC

0
200
400
600
825 a.a.

Protein Preferred Names	Protein Names
NT-3 growth factor receptor	GP145-TrkC neurotrophin-3 trk-C trkC tyrosine kinase

Recombinant Ntrk3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71386	TrkC Protein, Mouse (HEK293, His)	Q6VNS1 (C32-T429)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131003	Taletrectinib	Inhibitor	99.63%	Unkown

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09634	NTRK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W070306	PDK1-IN-1	Inhibitor	99.95%	Unkown
HY-131003A	Taletrectinib free base	Inhibitor	/	Unkown
HY-101977A	(R,S)-Selitrectinib	Inhibitor	/	Unkown
HY-115541	BRD4-IN-41	Inhibitor	/	Unkown
HY-RS09635	Ntrk3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09636	Ntrk3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992308	Anti-TrkC Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk3	NCBI	NCBI:4916