Ogdh - oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Gene

Also Known as E1o; d1401; OGDH-E1; mKIAA4192; 2210403E04Rik; 2210412K19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18293

Summary

Enables oxoglutarate dehydrogenase (NAD+) activity. Acts upstream of or within brain development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Ogdh Products (9)

mRNA Protein Name
NM_001252282.1 NP_001239211.1 2-oxoglutarate dehydrogenase complex component E1 isoform 1
NM_001252283.1 NP_001239212.1 2-oxoglutarate dehydrogenase complex component E1 isoform 2
NM_001252287.2 NP_001239216.1 2-oxoglutarate dehydrogenase complex component E1 isoform 3 precursor
NM_001252288.1 NP_001239217.1 2-oxoglutarate dehydrogenase complex component E1 isoform 4
NM_001361902.1 NP_001348831.1 2-oxoglutarate dehydrogenase complex component E1 isoform 2
NM_001361903.1 NP_001348832.1 2-oxoglutarate dehydrogenase complex component E1 isoform 2
NM_001361904.1 NP_001348833.1 2-oxoglutarate dehydrogenase complex component E1 isoform 3 precursor
NM_001361905.1 NP_001348834.1 2-oxoglutarate dehydrogenase complex component E1 isoform 4
NM_010956.4 NP_035086.2 2-oxoglutarate dehydrogenase complex component E1 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxoglutarate dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
17322295 MGI
Biological Process GO Annotation Evidence References Source
involved in cerebellar cortex development IEP
IEP: Inferred from expression pattern
16901643 MGI
involved in hippocampus development IEP
IEP: Inferred from expression pattern
16901643 MGI
involved in olfactory bulb mitral cell layer development IEP
IEP: Inferred from expression pattern
16901643 MGI
involved in pyramidal neuron development IEP
IEP: Inferred from expression pattern
16901643 MGI
involved in striatum development IEP
IEP: Inferred from expression pattern
16901643 MGI
involved in tangential migration from the subventricular zone to the olfactory bulb IEP
IEP: Inferred from expression pattern
16901643 MGI
involved in thalamus development IEP
IEP: Inferred from expression pattern
16901643 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
17322295 MGI
part of oxoglutarate dehydrogenase complex IMP
IMP: Inferred from mutant phenotype
22169199 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

2-oxoglutarate dehydrogenase complex component E1

2-oxoglutarate dehydrogenase, mitochondrial

  • OGDC-E1

  • alpha-KGDH-E1

  • alpha-ketoglutarate dehydrogenase

  • oxoglutarate dehydrogenase (lipoamide)

  • thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase

Recombinant Ogdh Proteins

Cat. No. Product Name Accession Purity
HY-P71567 OGDC-E Protein, Mouse (His-SUMO) Q60597 (V695-S1023) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12688A Succinyl phosphonate trisodium salt Inhibitor 98.0% Unkown
HY-RS17494 Ogdh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09758 OGDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23951 Ogdh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ogdh NCBI NCBI:4967