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Oprl1 - opioid receptor-like 1 Gene

Also Known as NOP; KOR3; ORGC; ORL1; Oprl; XOR1; morc; KOR-3; LC132; MOR-C

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18389

About Oprl1

Chromosome 2: 181,356,809-181,362,778 forward strand.GRCm39:CM000995.3

This gene has 12 transcripts (splice variants), 202 orthologues, 15 paralogues and is associated with 24 phenotypes. Biased expression in whole brain E14.5 (RPKM 16.2), CNS E18 (RPKM 14.7) and 6 other tissues.

Summary

The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Oprl1 Products (16)

mRNA	Protein	Name
NM_001252565.1	NP_001239494.1	nociceptin receptor isoform 1
NM_001318923.1	NP_001305852.1	nociceptin receptor isoform 4
NM_001318924.1	NP_001305853.1	nociceptin receptor isoform 5
NM_001318919.1	NP_001305848.1	nociceptin receptor isoform 1x
NM_001318922.1	NP_001305851.1	nociceptin receptor isoform 3
NM_001318925.1	NP_001305854.1	nociceptin receptor isoform 5
NM_001318920.1	NP_001305849.1	nociceptin receptor isoform 2
NM_011012.5	NP_035142.1	nociceptin receptor isoform 1
NM_001252565.1	NP_001239494.1	nociceptin receptor isoform 1
NM_001318919.1	NP_001305848.1	nociceptin receptor isoform 1x
NM_001318920.1	NP_001305849.1	nociceptin receptor isoform 2
NM_001318922.1	NP_001305851.1	nociceptin receptor isoform 3
NM_001318923.1	NP_001305852.1	nociceptin receptor isoform 4
NM_001318924.1	NP_001305853.1	nociceptin receptor isoform 5
NM_001318925.1	NP_001305854.1	nociceptin receptor isoform 5
NM_011012.5	NP_035142.1	nociceptin receptor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nociceptin receptor activity	IGI IGI: Inferred from genetic interaction	19448152	MGI
enables nociceptin receptor activity	IMP IMP: Inferred from mutant phenotype	12217419	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in neuron-neuron synaptic transmission	IGI IGI: Inferred from genetic interaction	19448152	MGI
involved in sensory perception of pain	IGI IGI: Inferred from genetic interaction	19448152	MGI
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	12217419	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in synaptic membrane	IGI IGI: Inferred from genetic interaction	19448152	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Oprl1 Protein Structure

7tmA_NOFQ_opioid_R

0
100
200
300
367 a.a.

Protein Preferred Names	Protein Names
nociceptin receptor	K3 opiate receptor N/OFQ receptor kappa-type 3 opioid receptor nociceptin/ orphaninFQ receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09803	OPRL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09804	Oprl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09805	Oprl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Oprl1	NCBI	NCBI:4987