P4ha1 - procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide Gene

Also Known as P4ha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18451

Summary

Enables procollagen-proline 4-dioxygenase activity. Acts upstream of or within Collagen fibril organization and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Part of procollagen-proline 4-dioxygenase complex. Is expressed in several structures, including genitourinary system; jaw; limb; sensory organ; and skeleton. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

P4ha1 Products (3)

mRNA Protein Name
NM_001316370.1 NP_001303299.1 prolyl 4-hydroxylase subunit alpha-1 isoform 1 precursor
NM_001316371.1 NP_001303300.1 prolyl 4-hydroxylase subunit alpha-1 isoform 2 precursor
NM_011030.2 NP_035160.1 prolyl 4-hydroxylase subunit alpha-1 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables procollagen-proline 4-dioxygenase activity IDA
IDA: Inferred from direct assay
7753822 MGI
enables procollagen-proline 4-dioxygenase activity IMP
IMP: Inferred from mutant phenotype
17135260 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
17135260 MGI
acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline IDA
IDA: Inferred from direct assay
7753822 MGI
Cellular Component GO Annotation Evidence References Source
part of procollagen-proline 4-dioxygenase complex IDA
IDA: Inferred from direct assay
7753822 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolyl 4-hydroxylase subunit alpha-1

  • 4-PH alpha-1

  • procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-121172 1,4-DPCA Inhibitor 99.78% Unkown
HY-RS09942 P4HA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16973 P4ha1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23416 P4ha1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P4ha1 NCBI NCBI:5033