P4ha2 - procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide Gene

Also Known as P4hl

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18452

Summary

Enables procollagen-proline 4-dioxygenase activity. Acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Part of procollagen-proline 4-dioxygenase complex. Is expressed in alimentary system; pectoral girdle and thoracic body wall musculature; and skeleton. Human ortholog(s) of this gene implicated in myopia. Orthologous to human P4HA2 (prolyl 4-hydroxylase subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

P4ha2 Products (2)

mRNA Protein Name
NM_001136076.2 NP_001129548.1 prolyl 4-hydroxylase subunit alpha-2 isoform 1 precursor
NM_011031.2 NP_035161.2 prolyl 4-hydroxylase subunit alpha-2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables procollagen-proline 4-dioxygenase activity IDA
IDA: Inferred from direct assay
7753822 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7753822 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline IDA
IDA: Inferred from direct assay
7753822 MGI
Cellular Component GO Annotation Evidence References Source
part of procollagen-proline 4-dioxygenase complex IDA
IDA: Inferred from direct assay
7753822 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolyl 4-hydroxylase subunit alpha-2

  • 4-PH alpha-2

  • Prolyl 4-hydroxylase alpha IIa subunit

  • procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-121172 1,4-DPCA Inhibitor 99.78% Unkown
HY-N2589 Isosaponarin 99.59% Unkown
HY-RS09943 P4HA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18674 P4ha2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25160 P4ha2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P4ha2 NCBI NCBI:8974