Pcsk1 - proprotein convertase subtilisin/kexin type 1 Gene

Also Known as PC1; PC3; Nec1; SPC3; Nec-1; Phpp-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18548

Summary

Enables identical protein binding activity and serine-type endopeptidase activity. Involved in peptide biosynthetic process and peptide hormone processing. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; female reproductive system; and nose. Used to study obesity. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk1 Products (1)

mRNA Protein Name
NM_013628.3 NP_038656.1 neuroendocrine convertase 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
9242664 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
19376969 MGI
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
8262946 MGI
enables serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
12136131 MGI
Biological Process GO Annotation Evidence References Source
involved in insulin processing IMP
IMP: Inferred from mutant phenotype
12136131 MGI
involved in peptide biosynthetic process IDA
IDA: Inferred from direct assay
8262946 MGI
involved in peptide hormone processing IDA
IDA: Inferred from direct assay
8262946 MGI
involved in protein processing IDA
IDA: Inferred from direct assay
9242664 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
8397508 MGI
is active in secretory granule IDA
IDA: Inferred from direct assay
12136131 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroendocrine convertase 1

  • furin homolog

  • prohormone convertase 1

  • prohormone convertase 1/3

  • propeptide-processing protease

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10170 PCSK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10171 PCSK1N Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18538 Pcsk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25020 Pcsk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcsk1 NCBI NCBI:5122