Etv4 - ets variant 4 Gene

Also Known as Pea3; Pea-3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18612

Summary

Enables DNA binding activity. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; motor neuron axon guidance; and negative regulation of mammary gland epithelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and urinary system. Orthologous to human ETV4 (ETS variant transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Etv4 Products (3)

mRNA	Protein	Name
NM_001316365.1	NP_001303294.1	ETS translocation variant 4 isoform 1
NM_001316366.1	NP_001303295.1	ETS translocation variant 4 isoform 3
NM_008815.3	NP_032841.2	ETS translocation variant 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12527199	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within branching involved in mammary gland duct morphogenesis	IDA IDA: Inferred from direct assay	12871699	MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	18977342	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	12372283	MGI
acts upstream of or within negative regulation of mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18977342	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15466854	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IPI IPI: Inferred from physical interaction	15466854	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	15253939	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22014525	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	18977342	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22014525	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	10482234	MGI
located in nucleus	IDA IDA: Inferred from direct assay	25512490	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ETS translocation variant 4	ETS variant protein 4 POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4) ets variant gene 4 (E1A enhancer binding protein, E1AF)

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-174866	BT-O2C	Inhibitor	99.31%	Unkown
HY-RS04567	ETV4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22164	Etv4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28686	Etv4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Etv4	NCBI	NCBI:2118