Pln - phospholamban Gene

Also Known as Plb

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18821

Summary

Enables protein homodimerization activity. Involved in negative regulation of calcium ion import into sarcoplasmic reticulum. Acts upstream of or within several processes, including negative regulation of calcium ion binding activity; regulation of calcium ion transport; and regulation of heart contraction. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; ear; heart; nervous system; and skeleton. Used to study centronuclear myopathy and dilated cardiomyopathy 1P. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban). [provided by Alliance of Genome Resources, Apr 2022]

Pln Products (2)

mRNA Protein Name
NM_001141927.1 NP_001135399.1 cardiac phospholamban
NM_023129.5 NP_075618.1 cardiac phospholamban

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase inhibitor activity IDA
IDA: Inferred from direct assay
22971924 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15201433 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
30299255 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
23117660 MGI
involved in acrosome assembly IDA
IDA: Inferred from direct assay
30733280 MGI
acts upstream of or within adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IMP
IMP: Inferred from mutant phenotype
10471356 MGI
acts upstream of or within cardiac muscle tissue development IGI
IGI: Inferred from genetic interaction
10555147 MGI
involved in circadian sleep/wake cycle, sleep IMP
IMP: Inferred from mutant phenotype
38493225 MGI
involved in intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
30733280 MGI
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
10555147 MGI
involved in locomotor rhythm IMP
IMP: Inferred from mutant phenotype
38493225 MGI
acts upstream of or within muscle cell cellular homeostasis IGI
IGI: Inferred from genetic interaction
10555147 MGI
acts upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity IDA
IDA: Inferred from direct assay
27923914 MGI
involved in negative regulation of ATPase-coupled calcium transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
30299255 MGI
acts upstream of or within negative regulation of calcium ion binding IDA
IDA: Inferred from direct assay
27923914 MGI
involved in negative regulation of calcium ion import into sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
30299255 MGI
acts upstream of or within negative regulation of heart contraction IGI
IGI: Inferred from genetic interaction
10555147 MGI
acts upstream of or within negative regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
8062415 MGI
acts upstream of or within regulation of calcium ion import IMP
IMP: Inferred from mutant phenotype
8620604 MGI
acts upstream of or within regulation of cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
8620604 MGI
acts upstream of or within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
IMP: Inferred from mutant phenotype
8831698 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
8831698 MGI
acts upstream of or within regulation of relaxation of muscle IMP
IMP: Inferred from mutant phenotype
10024311 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
9118481 MGI
acts upstream of or within regulation of ryanodine-sensitive calcium-release channel activity IMP
IMP: Inferred from mutant phenotype
10603936 MGI
acts upstream of or within regulation of the force of heart contraction IGI
IGI: Inferred from genetic interaction
10555147 MGI
acts upstream of or within regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
9118481 MGI
acts upstream of or within regulation of the force of heart contraction by cardiac conduction IMP
IMP: Inferred from mutant phenotype
10644605 MGI
involved in spermatogenesis IDA
IDA: Inferred from direct assay
30733280 MGI
involved in visual learning IMP
IMP: Inferred from mutant phenotype
38493225 MGI
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
30733280 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
27923914 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
9038922 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
26816378 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cardiac phospholamban

Pln Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Pln P61014 CAMK2D Homo sapiens Q13557
Pull Down
32873725
Cross
Pln P61014 CAMK2D Homo sapiens Q13557
Protein Kinase Assay
32873725
Cross
Pln P61014 YWHAG Homo sapiens P61981
Pull Down
32873725
Intra
Pln P61014 Prkaca Mus musculus P05132
Protein Kinase Assay
32873725
Intra
Pln P61014 Prkaca Mus musculus P05132
Pull Down
32873725
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-137561 Bexotegrast Inhibitor 99.74% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-47888 PLN-1474 Inhibitor 99.35% Unkown
HY-148776 PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 50:50) / Unkown
HY-137561A Bexotegrast hydrochloride Inhibitor / Unkown
HY-RS10727 PLN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17361 Pln Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23815 Pln Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pln NCBI NCBI:5350