Pou2f2 - POU domain, class 2, transcription factor 2 Gene

Also Known as Otf2; Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18987

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in cellular response to virus; positive regulation of interleukin-6 production; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within cell maturation; mature B cell differentiation; and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; nervous system; sensory organ; and thymus. Orthologous to human POU2F2 (POU class 2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Pou2f2 Products (4)

mRNA	Protein	Name
NM_001163554.1	NP_001157026.1	POU domain, class 2, transcription factor 2 isoform 4
NM_001163555.1	NP_001157027.1	POU domain, class 2, transcription factor 2 isoform 3
NM_001163556.1	NP_001157028.1	POU domain, class 2, transcription factor 2 isoform 1
NM_011138.2	NP_035268.2	POU domain, class 2, transcription factor 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11937630	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11937630	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11937630	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11937630	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	7720710	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7720710	MGI
enables spermidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	23458604	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	23045607	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	14978099	MGI
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	23045607	MGI
acts upstream of or within immunoglobulin production	IMP IMP: Inferred from mutant phenotype	14978099	MGI
acts upstream of or within immunoglobulin production involved in immunoglobulin-mediated immune response	IMP IMP: Inferred from mutant phenotype	8096198	MGI
acts upstream of or within mature B cell differentiation	IMP IMP: Inferred from mutant phenotype	8096198	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11937630	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	23045607	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11937630	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14978099	MGI
involved in spermidine transport	IDA IDA: Inferred from direct assay	23458604	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	11937630	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
POU domain, class 2, transcription factor 2	lymphoid-restricted immunoglobulin octamer-binding protein NF-A2 octamer-binding protein 2 octamer-binding transcription factor 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10898	POU2F2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20583	Pou2f2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27091	Pou2f2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou2f2	NCBI	NCBI:5452