Ppp3ca - protein phosphatase 3, catalytic subunit, alpha isoform Gene

Mus musculus

Also known as CN; CnA; Caln; Calna; 2900074D19Rik

Gene ID: 19055 | Gene type: protein coding

About Ppp3ca

Summary

Enables Calmodulin binding activity and calmodulin-dependent protein Phosphatase activity. Involved in several processes, including negative regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of cardiac muscle hypertrophy in response to stress; and positive regulation of connective tissue replacement. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; cardiac muscle hypertrophy in response to stress; and regulation of transcription, DNA-templated. Located in several cellular components, including Z disc; cytosol; and mitochondrion. Part of Calcineurin complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; jaw; and thymus primordium. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein Phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3ca Products(2)

mRNA	Protein	Name
NM_001293622.1	NP_001280551.1	protein phosphatase 3 catalytic subunit alpha isoform 2
NM_008913.5	NP_032939.1	protein phosphatase 3 catalytic subunit alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	26794871	MGI
enables calmodulin-dependent protein phosphatase activity	IDA IDA: Inferred from direct assay	26794871	MGI
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	16024798	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12574411	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12660151	MGI
acts upstream of or within calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	9017603	MGI
acts upstream of or within calcineurin-NFAT signaling cascade	IGI IGI: Inferred from genetic interaction	18676376	MGI
acts upstream of or within calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	9515963	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	12660151	MGI
acts upstream of or within calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	19560418	MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress	IGI IGI: Inferred from genetic interaction	12370307	MGI
acts upstream of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	23407945	MGI
acts upstream of or within dephosphorylation	IDA IDA: Inferred from direct assay	12574411	MGI
involved in epidermis development	IMP IMP: Inferred from mutant phenotype	19626032	MGI
acts upstream of or within excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	17428973	MGI
involved in keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	19626032	MGI
acts upstream of or within modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	15590926	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	10200317	MGI
acts upstream of or within multicellular organismal response to stress	IDA IDA: Inferred from direct assay	11782539	MGI
acts upstream of or within negative regulation of chromatin binding	IMP IMP: Inferred from mutant phenotype	23407945	MGI
acts upstream of or within negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	23407945	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	24161931	MGI
involved in negative regulation of signaling	IMP IMP: Inferred from mutant phenotype	26029823	MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23261540	MGI
involved in positive regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	8627154	MGI
involved in positive regulation of cardiac muscle hypertrophy	IGI IGI: Inferred from genetic interaction	24161931	MGI
involved in positive regulation of cardiac muscle hypertrophy in response to stress	IDA IDA: Inferred from direct assay	19287093	MGI
involved in positive regulation of connective tissue replacement	IGI IGI: Inferred from genetic interaction	24657879	MGI
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	20032460	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	24161931	MGI
involved in positive regulation of glomerulus development	IMP IMP: Inferred from mutant phenotype	15509543	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	16286645	MGI
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	16968888	MGI
involved in positive regulation of saliva secretion	IMP IMP: Inferred from mutant phenotype	21435446	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12808150	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17229811	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24161931	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	11257222	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	11257222	MGI
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	26794871	MGI
acts upstream of or within protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	19560418	MGI
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	11782539	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	31637311	MGI
involved in regulation of cell proliferation involved in kidney morphogenesis	IMP IMP: Inferred from mutant phenotype	15509543	MGI
involved in renal filtration	IMP IMP: Inferred from mutant phenotype	16735444	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	16024798	MGI
involved in skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	12773574	MGI
acts upstream of or within transition between fast and slow fiber	IDA IDA: Inferred from direct assay	21427212	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	11257222	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	11257222	MGI
located in Z disc	IDA IDA: Inferred from direct assay	15665106	MGI
part of calcineurin complex	IDA IDA: Inferred from direct assay	12617961	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16286645	MGI
located in cytosol	IDA IDA: Inferred from direct assay	12617961	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11257222	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11257222	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	12617961	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12617961	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein phosphatase 3 catalytic subunit alpha

serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

CAM-PRP catalytic subunit	CNA alpha
PP2B alpha 1	PP2BA alpha
calcineurin A alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11023	PPP3CA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19521	Ppp3ca Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26016	Ppp3ca Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp3ca	NCBI	NCBI:5530

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