Ptch1 - patched 1 Gene

Mus musculus

Also known as Ptc; mes; wig; Ptc1; Ptch; A230106A15Rik

Gene ID: 19206 | Gene type: protein coding

About Ptch1

Summary

Enables cyclin binding activity; heparin binding activity; and patched binding activity. Involved in several processes, including chordate embryonic development; negative regulation of smoothened signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and limb morphogenesis. Located in cilium; midbody; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and urinary system. Used to study basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in basal cell carcinoma; holoprosencephaly; holoprosencephaly 7; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH1 (patched 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptch1 Products(2)

mRNA	Protein	Name
NM_001328514.1	NP_001315443.1	protein patched homolog 1 isoform b
NM_008957.3	NP_032983.1	protein patched homolog 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cyclin binding	IPI IPI: Inferred from physical interaction	11331587	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	10500113	MGI
enables patched binding	IDA IDA: Inferred from direct assay	10500113	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10500113	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11331587	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	12917290	MGI
involved in brain development	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	19809516	MGI
acts upstream of or within cell differentiation involved in kidney development	IGI IGI: Inferred from genetic interaction	19809516	MGI
acts upstream of or within cell fate determination	IGI IGI: Inferred from genetic interaction	24492243	MGI
acts upstream of or within cell proliferation involved in metanephros development	IMP IMP: Inferred from mutant phenotype	19809516	MGI
involved in cellular response to cholesterol	IEP IEP: Inferred from expression pattern	21931618	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	9262482	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	15576403	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	11389830	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	11784021	MGI
acts upstream of or within embryonic organ development	IGI IGI: Inferred from genetic interaction	24302887	MGI
acts upstream of or within epidermal cell fate specification	IGI IGI: Inferred from genetic interaction	24492243	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	17631878	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17631878	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	11044404	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	9262482	MGI
acts upstream of or within hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	9262482	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	21406566	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	17631878	MGI
acts upstream of or within keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	17631878	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	10529434	MGI
acts upstream of or within mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	10529434	MGI
acts upstream of or within mammary gland epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	10529434	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24548465	MGI
involved in negative regulation of cell division	IMP IMP: Inferred from mutant phenotype	11331587	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16489008	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11331587	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17631878	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	17631878	MGI
acts upstream of or within negative regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	11784021	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IDA IDA: Inferred from direct assay	9006067	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	19004860	MGI
involved in negative regulation of smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	21931618	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	11784021	MGI
acts upstream of or within negative regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17631878	MGI
involved in neural plate axis specification	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	9262482	MGI
involved in neural tube formation	IDA IDA: Inferred from direct assay	10500113	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	9262482	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24548465	MGI
acts upstream of or within positive regulation of epidermal cell differentiation	IGI IGI: Inferred from genetic interaction	24492243	MGI
acts upstream of or within protein processing	IMP IMP: Inferred from mutant phenotype	16061793	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19809516	MGI
acts upstream of or within regulation of growth	IMP IMP: Inferred from mutant phenotype	9262482	MGI
acts upstream of or within regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16489008	MGI
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	11331587	MGI
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	16489008	MGI
acts upstream of or within response to chlorate	IDA IDA: Inferred from direct assay	11476578	MGI
involved in signal transduction	IDA IDA: Inferred from direct assay	10500113	MGI
involved in somite development	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within spinal cord motor neuron differentiation	IGI IGI: Inferred from genetic interaction	21552265	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17631878	MGI
acts upstream of or within stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17631878	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	19654211	MGI
located in midbody	IDA IDA: Inferred from direct assay	15166316	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11331587	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein patched homolog 1

Ptch1 protein +12b	mesenchymal dysplasia
patched homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10875	HL2-m5	Inhibitor	98.06%	Unkown
HY-137567	Prostaglandin E1 ethanolamide	Activator	/	Unkown
HY-153499	SMO-IN-4	Antagonist	/	Unkown
HY-183335	SMO-IN-6		/	Unkown
HY-RS11356	PTCH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18678	Ptch1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25164	Ptch1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptch1	NCBI	NCBI:5727

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