Ptch1 - patched 1 Gene

Also Known as Ptc; mes; wig; Ptc1; Ptch; A230106A15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19206

Summary

Enables cyclin binding activity; heparin binding activity; and patched binding activity. Involved in several processes, including chordate embryonic development; negative regulation of smoothened signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and limb morphogenesis. Located in cilium; midbody; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and urinary system. Used to study basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in basal cell carcinoma; holoprosencephaly; holoprosencephaly 7; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH1 (patched 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptch1 Products (2)

mRNA Protein Name
NM_001328514.1 NP_001315443.1 protein patched homolog 1 isoform b
NM_008957.3 NP_032983.1 protein patched homolog 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
11331587 MGI
enables heparin binding IDA
IDA: Inferred from direct assay
10500113 MGI
enables patched binding IDA
IDA: Inferred from direct assay
10500113 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10500113 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
11331587 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
12917290 MGI
involved in brain development IMP
IMP: Inferred from mutant phenotype
11517919 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
19809516 MGI
acts upstream of or within cell differentiation involved in kidney development IGI
IGI: Inferred from genetic interaction
19809516 MGI
acts upstream of or within cell fate determination IGI
IGI: Inferred from genetic interaction
24492243 MGI
acts upstream of or within cell proliferation involved in metanephros development IMP
IMP: Inferred from mutant phenotype
19809516 MGI
involved in cellular response to cholesterol IEP
IEP: Inferred from expression pattern
21931618 MGI
acts upstream of or within dorsal/ventral neural tube patterning IMP
IMP: Inferred from mutant phenotype
9262482 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
15576403 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
11389830 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
11784021 MGI
acts upstream of or within embryonic organ development IGI
IGI: Inferred from genetic interaction
24302887 MGI
acts upstream of or within epidermal cell fate specification IGI
IGI: Inferred from genetic interaction
24492243 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
17631878 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17631878 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
11044404 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
9262482 MGI
acts upstream of or within hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
9262482 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
21406566 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
17631878 MGI
acts upstream of or within keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
17631878 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
10529434 MGI
acts upstream of or within mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
10529434 MGI
acts upstream of or within mammary gland epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
10529434 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
24548465 MGI
involved in negative regulation of cell division IMP
IMP: Inferred from mutant phenotype
11331587 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16489008 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11331587 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17631878 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
17631878 MGI
acts upstream of or within negative regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
11784021 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
9006067 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
19004860 MGI
involved in negative regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
21931618 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
11784021 MGI
acts upstream of or within negative regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17631878 MGI
involved in neural plate axis specification IMP
IMP: Inferred from mutant phenotype
11517919 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
9262482 MGI
involved in neural tube formation IDA
IDA: Inferred from direct assay
10500113 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
9262482 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
24548465 MGI
acts upstream of or within positive regulation of epidermal cell differentiation IGI
IGI: Inferred from genetic interaction
24492243 MGI
acts upstream of or within protein processing IMP
IMP: Inferred from mutant phenotype
16061793 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19809516 MGI
acts upstream of or within regulation of growth IMP
IMP: Inferred from mutant phenotype
9262482 MGI
acts upstream of or within regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
16489008 MGI
involved in regulation of protein localization IDA
IDA: Inferred from direct assay
11331587 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
16489008 MGI
acts upstream of or within response to chlorate IDA
IDA: Inferred from direct assay
11476578 MGI
involved in signal transduction IDA
IDA: Inferred from direct assay
10500113 MGI
involved in somite development IMP
IMP: Inferred from mutant phenotype
11517919 MGI
acts upstream of or within spinal cord motor neuron differentiation IGI
IGI: Inferred from genetic interaction
21552265 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17631878 MGI
acts upstream of or within stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17631878 MGI
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
19654211 MGI
located in midbody IDA
IDA: Inferred from direct assay
15166316 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11331587 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein patched homolog 1

  • Ptch1 protein +12b

  • mesenchymal dysplasia

  • patched homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10875 HL2-m5 Inhibitor 98.06% Unkown
HY-137567 Prostaglandin E1 ethanolamide Activator / Unkown
HY-153499 SMO-IN-4 Antagonist / Unkown
HY-183335 SMO-IN-6 / Unkown
HY-RS11356 PTCH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18678 Ptch1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25164 Ptch1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptch1 NCBI NCBI:5727