Syngap1 - synaptic Ras GTPase activating protein 1 Gene

Also Known as Syngap

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 192117

Summary

This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and Phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations in mice result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]

Syngap1 Products (2)

mRNA Protein Name
NM_001113409.3 NP_001106880.2 ras/Rap GTPase-activating protein SynGAP isoform 2
NM_181092.5 NP_851606.3 ras/Rap GTPase-activating protein SynGAP isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
14970204 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16054660 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12951199 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Ras protein signal transduction IDA
IDA: Inferred from direct assay
21382555 RGD
involved in regulation of synaptic plasticity IDA
IDA: Inferred from direct assay
21382555 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21736925 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
21736925 RGD
located in synapse IDA
IDA: Inferred from direct assay
9620694 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras/Rap GTPase-activating protein SynGAP

  • neuronal RasGAP

  • p135 SynGAP

  • ras GTPase-activating protein SynGAP

  • synaptic Ras-GAP 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-180779 SR-1815 / Unkown
HY-RS14089 SYNGAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20656 Syngap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27167 Syngap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syngap1 NCBI NCBI:8831