Ptgs1 - prostaglandin-endoperoxide synthase 1 Gene

Also Known as COX1; Cox-1; Cox-3; PHS 1; Pghs1; PGHS-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19224

Summary

This is one of two genes encoding similar Enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]

Ptgs1 Products (1)

mRNA Protein Name
NM_008969.4 NP_032995.1 prostaglandin G/H synthase 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within prostaglandin biosynthetic process IMP
IMP: Inferred from mutant phenotype
12093889 MGI
acts upstream of or within prostaglandin metabolic process IMP
IMP: Inferred from mutant phenotype
10987272 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
12093889 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
10987272 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12021206 MGI
NOT located in nucleus IDA
IDA: Inferred from direct assay
12021206 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
12355421 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostaglandin G/H synthase 1

  • PGH synthase 1

  • cyclooxygenase-1

  • prostaglandin H2 synthase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11392 PTGS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19231 Ptgs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25720 Ptgs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptgs1 NCBI NCBI:5742