Pthlh - parathyroid hormone-like peptide Gene

Also Known as PLP; Pthrp; PTH-like

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19227

Summary

This gene encodes a member of the parathyroid family of Hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of Apoptosis. The encoded protein undergoes proteolytic processing to generate multiple active peptides with distinct signaling functions. The homozygous deletion of this gene leads to death shortly after birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation. [provided by RefSeq, Jul 2015]

Pthlh Products (1)

mRNA Protein Name
NM_008970.4 NP_032996.2 parathyroid hormone-related protein preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
NOT acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
11606467 MGI
acts upstream of bone mineralization IMP
IMP: Inferred from mutant phenotype
19968565 MGI
acts upstream of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
8895385 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
8895385 MGI
acts upstream of or within endoderm development IDA
IDA: Inferred from direct assay
9921650 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
15162506 MGI
acts upstream of or within lung epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
15162506 MGI
acts upstream of or within mammary gland bud elongation IMP
IMP: Inferred from mutant phenotype
9477327 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17328886 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IDA
IDA: Inferred from direct assay
17328886 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
17328886 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
8895385 MGI
acts upstream of or within nipple sheath formation IMP
IMP: Inferred from mutant phenotype
9477327 MGI
acts upstream of or within osteoblast development IMP
IMP: Inferred from mutant phenotype
9832460 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17328886 MGI
acts upstream of or within protein processing IDA
IDA: Inferred from direct assay
17328886 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
8314082 MGI
acts upstream of or within surfactant homeostasis IMP
IMP: Inferred from mutant phenotype
15162506 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
8895385 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26859332 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

parathyroid hormone-related protein

  • PTH-related peptide

  • parathyroid hormone-like hormone

  • parathyroid hormone-like protein

  • parathyroid hormone-related peptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11398 PTHLH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21704 Pthlh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28222 Pthlh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pthlh NCBI NCBI:5744