Rab17 - RAB17, member RAS oncogene family Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19329

Summary

Predicted to enable GDP binding activity and GTPase activity. Involved in several processes, including immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; melanosome transport; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; metanephros; olfactory epithelium; and testis. Orthologous to human RAB17 (RAB17, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab17 Products (2)

mRNA	Protein	Name
NM_001159725.2	NP_001153197.2	ras-related protein Rab-17
NM_008998.4	NP_033024.1	ras-related protein Rab-17

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19368996	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in anterograde dendritic transport	IDA IDA: Inferred from direct assay	24895134	MGI
involved in anterograde dendritic transport	IMP IMP: Inferred from mutant phenotype	24895134	MGI
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	9490718	MGI
NOT involved in endocytosis	IMP IMP: Inferred from mutant phenotype	9624171	MGI
involved in establishment of melanosome localization	IMP IMP: Inferred from mutant phenotype	21291502	MGI
involved in filopodium assembly	IMP IMP: Inferred from mutant phenotype	21291502	MGI
involved in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IMP IMP: Inferred from mutant phenotype	9624171	MGI
involved in melanosome transport	IMP IMP: Inferred from mutant phenotype	21291502	MGI
involved in regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	22291024	MGI
involved in regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	22291024	MGI
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	22291024	MGI
involved in transcytosis	IMP IMP: Inferred from mutant phenotype	9490718	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	8486736	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	8486736	MGI
located in dendrite	IDA IDA: Inferred from direct assay	22291024	MGI
NOT located in early endosome	IDA IDA: Inferred from direct assay	21291502	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24895134	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24895134	MGI
located in melanosome	IDA IDA: Inferred from direct assay	21291502	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	22291024	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	24895134	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	24895134	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	9490718	MGI
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	9624171	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ras-related protein Rab-17

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11525	RAB17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29450	Rab17 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab17	NCBI	NCBI:64284