Rfx2 - regulatory factor X, 2 (influences HLA class II expression) Gene

Also Known as 5430432H19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19725

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in acrosome assembly; cilium assembly; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; liver; ovary; primitive streak; and sensory organ. Orthologous to human RFX2 (regulatory factor X2). [provided by Alliance of Genome Resources, Apr 2022]

Rfx2 Products (2)

mRNA Protein Name
NM_009056.3 NP_033082.1 DNA-binding protein RFX2 isoform 2
NM_027787.2 NP_082063.1 DNA-binding protein RFX2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
14743396 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
26162102 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
26162102 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
8289803 MGI
Biological Process GO Annotation Evidence References Source
involved in acrosome assembly IMP
IMP: Inferred from mutant phenotype
26162102 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
26162102 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
14743396 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
26162102 MGI
involved in spermatid development IMP
IMP: Inferred from mutant phenotype
26162102 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-binding protein RFX2

  • regulatory factor X 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11880 RFX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22299 Rfx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28822 Rfx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rfx2 NCBI NCBI:5990