Rps6ka2 - ribosomal protein S6 kinase, polypeptide 2 Gene

Also Known as Rsk3; 90kDa; p90rsk; pp90rsk; D17Wsu134e; Rps6ka-rs1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20112

About Rps6ka2

Chromosome 17: 7,437,514-7,570,714 forward strand.GRCm39:CM001010.3

This gene has 5 transcripts (splice variants), 209 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary adult (RPKM 18.1), heart adult (RPKM 11.1) and 25 other tissues.

Summary

Enables ribosomal protein S6 kinase activity. Acts upstream of or within several processes, including cardiac muscle cell apoptotic process; oocyte maturation; and regulation of gene expression. Located in cytoplasm and meiotic spindle. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human RPS6KA2 (ribosomal protein S6 kinase A2). [provided by Alliance of Genome Resources, Apr 2022]

Rps6ka2 Products (2)

mRNA	Protein	Name
NM_011299.4	NP_035429.1	ribosomal protein S6 kinase alpha-2
NM_011299.4	NP_035429.1	ribosomal protein S6 kinase alpha-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15526037	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	15526037	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	7508917	MGI
enables ribosomal protein S6 kinase activity	IDA IDA: Inferred from direct assay	16585392	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within brain renin-angiotensin system	IDA IDA: Inferred from direct assay	16585392	MGI
acts upstream of or within cardiac muscle cell apoptotic process	IDA IDA: Inferred from direct assay	16585392	MGI
acts upstream of or within cellular response to carbohydrate stimulus	IDA IDA: Inferred from direct assay	16585392	MGI
acts upstream of or within heart contraction	IDA IDA: Inferred from direct assay	16585392	MGI
acts upstream of or within heart development	IDA IDA: Inferred from direct assay	16585392	MGI
acts upstream of or within negative regulation of meiotic nuclear division	IDA IDA: Inferred from direct assay	15526037	MGI
acts upstream of or within oocyte maturation	IDA IDA: Inferred from direct assay	15526037	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	7508917	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	16585392	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	15526037	MGI
acts upstream of or within regulation of protein processing	IMP IMP: Inferred from mutant phenotype	16585392	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15526037	MGI
located in meiotic spindle	IDA IDA: Inferred from direct assay	15526037	MGI
located in spindle	IDA IDA: Inferred from direct assay	15509711	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rps6ka2 Protein Structure

STKc_RSK_N

STKc_RSK3_C

0
200
400
600
733 a.a.

Protein Preferred Names	Protein Names
ribosomal protein S6 kinase alpha-2	90 kDa ribosomal protein S6 kinase 2 MAP kinase-activated protein kinase 1c MAPK-activated protein kinase 1c MAPKAP kinase 1c MAPKAPK-1c RSK-3 S6K-alpha 2 p90-RSK 2 p90RSK2 pp90RSK3 protein-tyrosine kinase Mpk-9 ribosomal S6 kinase 3 ribosomal protein S6 kinase, 90kD, polypeptide 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12251	RPS6KA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12252	Rps6ka2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12253	Rps6ka2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rps6ka2	NCBI	NCBI:6196