PLD6 - phospholipase D family member 6 Gene

Also Known as ZUC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201164

About PLD6

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,200,995-17,206,333 (from NCBI)

This gene has 1 transcript (splice variant) and 180 orthologues. Broad expression in testis (RPKM 12.6), prostate (RPKM 3.8) and 25 other tissues.

Summary

Enables cardiolipin hydrolase activity and protein homodimerization activity. Involved in mitochondrial fusion. Acts upstream of or within positive regulation of mitochondrial fusion. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLD6 Products (1)

mRNA Protein Name
NM_178836.4 NP_849158.2 mitochondrial cardiolipin hydrolase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cardiolipin hydrolase activity IDA
IDA: Inferred from direct assay
17028579 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26711011 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
17028579 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
17028579 GOA
acts upstream of or within positive regulation of mitochondrial fusion IDA
IDA: Inferred from direct assay
24599962 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
17028579 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLD6 Protein Structure

PLDc_2

PLDc_2: PLD-like domain (85 - 206)

  • 0
  • 100
  • 200
  • 252 a.a.
Protein Preferred Names Protein Names

mitochondrial cardiolipin hydrolase

  • PLD 6

Related Diseases

Diseases Alias
Heavy Chain Disease

  • Hcd
Pinguecula
Conjunctival Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10675 PLD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PLD6 VGNC VGNC:76145
Rattus norvegicus PLD6 RGD RGD:1311987
Bos taurus PLD6 VGNC VGNC:33000
Mus musculus PLD6 MGD MGI:2687283
Felis catus PLD6 VGNC VGNC:99319
Canis familiaris PLD6 VGNC VGNC:53434
Others PLD6 NCBI