Rxrg - retinoid X receptor gamma Gene

Also Known as Nr2b3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20183

About Rxrg

Chromosome 1: 167,425,953-167,467,192 forward strand.GRCm39:CM000994.3

This gene has 4 transcripts (splice variants), 277 orthologues, 11 paralogues and is associated with 9 phenotypes. Biased expression in heart adult (RPKM 24.1), CNS E18 (RPKM 1.1) and 1 other tissues.

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and nuclear receptor activity. Acts upstream of or within positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus and retinoic acid receptor signaling pathway. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]

Rxrg Products (2)

mRNA Protein Name
NM_001159731.1 NP_001153203.1 retinoic acid receptor RXR-gamma isoform 2
NM_009107.3 NP_033133.1 retinoic acid receptor RXR-gamma isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
1312497 MGI
enables sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
7823919 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
7823919 MGI
acts upstream of or within retinoic acid receptor signaling pathway IDA
IDA: Inferred from direct assay
1312497 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rxrg Protein Structure

Nuc_recep-AF1

Nuc_recep-AF1: pfam11825 (24 - 133)

NR_DBD_RXR

NR_DBD_RXR: cd06956 (136 - 212)

NR_LBD_RXR_like

NR_LBD_RXR_like: cd06943 (232 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
Protein Preferred Names Protein Names

retinoic acid receptor RXR-gamma

  • nuclear receptor subfamily 2 group B member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12364 Rxrg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12365 RXRG Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12363 RXRG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160212 JP3000 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rxrg NCBI NCBI:6258