Ncor1 - nuclear receptor co-repressor 1 Gene

Also Known as N-CoR; RIP13; Rxrip13; mKIAA1047; 5730405M06Rik; A230020K14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20185

Summary

Enables several functions, including histone deacetylase regulator activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in locomotor rhythm. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of signal transduction. Located in cytoplasm and nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human NCOR1 (nuclear receptor corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncor1 Products (3)

mRNA Protein Name
NM_001252313.1 NP_001239242.1 nuclear receptor corepressor 1 isoform 1
NM_011308.3 NP_035438.3 nuclear receptor corepressor 1 isoform 2
NM_177229.3 NP_796203.1 nuclear receptor corepressor 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14980219 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
17392792 MGI
enables histone deacetylase regulator activity IDA
IDA: Inferred from direct assay
19037247 MGI
enables histone deacetylase regulator activity IMP
IMP: Inferred from mutant phenotype
15695367 MGI
enables nuclear retinoic acid receptor binding IDA
IDA: Inferred from direct assay
8961273 MGI
enables nuclear retinoid X receptor binding IDA
IDA: Inferred from direct assay
7760852 MGI
enables nuclear thyroid hormone receptor binding IDA
IDA: Inferred from direct assay
8961273 MGI
enables nuclear thyroid hormone receptor binding IPI
IPI: Inferred from physical interaction
19052228 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9139821 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15175761 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17928865 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16127449 MGI
enables transcription corepressor activity IGI
IGI: Inferred from genetic interaction
7566114 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
11030619 MGI
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
11030619 MGI
acts upstream of or within cellular response to Thyroglobulin triiodothyronine IGI
IGI: Inferred from genetic interaction
24550004 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
19052228 MGI
acts upstream of or within circadian regulation of gene expression IGI
IGI: Inferred from genetic interaction
19037247 MGI
acts upstream of or within definitive erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
11030619 MGI
involved in epidermis development IGI
IGI: Inferred from genetic interaction
32467224 MGI
involved in establishment of skin barrier IGI
IGI: Inferred from genetic interaction
32467224 MGI
involved in gene expression IGI
IGI: Inferred from genetic interaction
32467224 MGI
involved in in utero embryonic development IGI
IGI: Inferred from genetic interaction
32467224 MGI
involved in locomotor rhythm IMP
IMP: Inferred from mutant phenotype
19037247 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15695367 MGI
acts upstream of or within negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15681609 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
24794873 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
17606624 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
7566114 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11328825 MGI
involved in protein stabilization IGI
IGI: Inferred from genetic interaction
32467224 MGI
acts upstream of or within regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
19037247 MGI
acts upstream of or within regulation of thyroid hormone receptor signaling pathway IGI
IGI: Inferred from genetic interaction
24550004 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19052228 MGI
acts upstream of or within thalamus development IMP
IMP: Inferred from mutant phenotype
11030619 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17606624 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11092755 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
17182846 MGI
part of transcription repressor complex IPI
IPI: Inferred from physical interaction
17182846 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor corepressor 1

  • N-CoR1

  • retinoid X receptor-interacting protein 13

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-121900 LT175 Agonist 99.46% Unkown
HY-176851 GSK1362 Inhibitor 96.38% Unkown
HY-177756 BCL6-IN-11 Inhibitor / Unkown
HY-RS09096 NCOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20452 Ncor1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26961 Ncor1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncor1 NCBI NCBI:9611