Scn9a - sodium channel, voltage-gated, type IX, alpha Gene

Also Known as PN1; Nav1.7; mKIAA4197

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20274

About Scn9a

Chromosome 2: 66,310,424-66,465,306 reverse strand.GRCm39:CM000995.3

This gene has 7 transcripts (splice variants), 111 orthologues, 26 paralogues and is associated with 19 phenotypes. Biased expression in CNS E18 (RPKM 4.9), whole brain E14.5 (RPKM 3.) and 6 other tissues.

Summary

Predicted to enable sodium ion binding activity and voltage-gated Sodium Channel activity. Acts upstream of or within several processes, including behavioral response to pain; inflammatory response; and response to toxic substance. Predicted to be integral component of plasma membrane. Predicted to be part of voltage-gated Sodium Channel complex. Predicted to be active in axon. Is expressed in several structures, including alimentary system; brain; immune system; male reproductive gland or organ; and respiratory system epithelium. Human ortholog(s) of this gene implicated in erythromelalgia; generalized epilepsy with febrile seizures plus 7; and paroxysmal extreme pain disorder. Orthologous to human SCN9A (sodium voltage-gated channel alpha subunit 9). [provided by Alliance of Genome Resources, Apr 2022]

Scn9a Products (2)

mRNA Protein Name
NM_001290674.1 NP_001277603.1 sodium channel protein type 9 subunit alpha isoform a
NM_001290675.1 NP_001277604.1 sodium channel protein type 9 subunit alpha isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
37117223 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to pain IMP
IMP: Inferred from mutant phenotype
15314237 MGI
involved in behavioral response to pain IMP
IMP: Inferred from mutant phenotype
24440715 MGI
involved in circadian rhythm IMP
IMP: Inferred from mutant phenotype
25101983 MGI
involved in detection of mechanical stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
25101983 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
25101983 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
15314237 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
15314237 MGI
acts upstream of or within response to toxic substance IDA
IDA: Inferred from direct assay
16029194 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn9a Protein Structure

Ion_trans

Ion_trans: pfam00520 (124 - 409)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (533 - 692)

Ion_trans

Ion_trans: pfam00520 (741 - 954)

Na_trans_assoc

Na_trans_assoc: pfam06512 (980 - 1184)

Ion_trans

Ion_trans: pfam00520 (1188 - 1463)

Na_channel_gate

Na_channel_gate: cd13433 (1455 - 1507)

Ion_trans

Ion_trans: pfam00520 (1511 - 1767)

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  • 1600
  • 1984 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 9 subunit alpha

  • peripheral sodium channel 1

  • sodium channel 25

  • sodium channel, voltage-gated, type IX, alpha polypeptide

  • voltage-gated sodium channel alpha subunit Nav1.7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12548 SCN9A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12549 Scn9a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12550 Scn9a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990503 Anti-SCN9a/Nav1.7 Antibody Inhibitor 98.57% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn9a NCBI NCBI:6335