2. Gene
  3. Scn9a - sodium channel, voltage-gated, type IX, alpha Gene

Scn9a - sodium channel, voltage-gated, type IX, alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PN1; Nav1.7; mKIAA4197

Gene ID: 20274 | Gene type: protein coding

About Scn9a

Chromosome 2: 66,310,424-66,465,306 reverse strand.GRCm39:CM000995.3

This gene has 7 transcripts (splice variants), 111 orthologues, 26 paralogues and is associated with 19 phenotypes. Biased expression in CNS E18 (RPKM 4.9), whole brain E14.5 (RPKM 3.) and 6 other tissues.

Summary

Predicted to enable sodium ion binding activity and voltage-gated Sodium Channel activity. Acts upstream of or within several processes, including behavioral response to pain; inflammatory response; and response to toxic substance. Predicted to be integral component of plasma membrane. Predicted to be part of voltage-gated Sodium Channel complex. Predicted to be active in axon. Is expressed in several structures, including alimentary system; brain; immune system; male reproductive gland or organ; and respiratory system epithelium. Human ortholog(s) of this gene implicated in erythromelalgia; generalized epilepsy with febrile seizures plus 7; and paroxysmal extreme pain disorder. Orthologous to human SCN9A (sodium voltage-gated channel alpha subunit 9). [provided by Alliance of Genome Resources, Apr 2022]

Scn9a Products(2)

mRNA Protein Name
NM_001290674.1 NP_001277603.1 sodium channel protein type 9 subunit alpha isoform a
NM_001290675.1 NP_001277604.1 sodium channel protein type 9 subunit alpha isoform b

Scn9a Protein Structure

Ion_trans

Ion_trans: pfam00520 (124 - 409)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (533 - 692)

Ion_trans

Ion_trans: pfam00520 (741 - 954)

Na_trans_assoc

Na_trans_assoc: pfam06512 (980 - 1184)

Ion_trans

Ion_trans: pfam00520 (1188 - 1463)

Na_channel_gate

Na_channel_gate: cd13433 (1455 - 1507)

Ion_trans

Ion_trans: pfam00520 (1511 - 1767)

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  • 1984 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 9 subunit alpha

peripheral sodium channel 1

sodium channel 25

sodium channel, voltage-gated, type IX, alpha polypeptide

voltage-gated sodium channel alpha subunit Nav1.7

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12548 SCN9A Human Pre-designed siRNA Set A / Unkown
HY-RS12549 Scn9a Mouse Pre-designed siRNA Set A / Unkown
HY-RS12550 Scn9a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn9a NCBI NCBI:6335