ENPEP - glutamyl aminopeptidase Gene

Homo sapiens

Also known as APA; CD249; gp160

Gene ID: 2028 | Gene type: protein coding

About ENPEP

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:110,476,155-110,565,285 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 11 paralogues. Biased expression in small intestine (RPKM 132.9), kidney (RPKM 71.6) and 5 other tissues.

Summary

The ENPEP gene encodes glutamyl Aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020]

ENPEP Products(4)

mRNA	Protein	Name
NM_001379611.1	NP_001366540.1	glutamyl aminopeptidase isoform 2
NM_001379612.1	NP_001366541.1	glutamyl aminopeptidase isoform 3
NM_001379613.1	NP_001366542.1	glutamyl aminopeptidase isoform 4
NM_001977.4	NP_001968.3	glutamyl aminopeptidase isoform 1

ENPEP Protein Structure

Peptidase_M1

ERAP1_C

0
200
400
600
800
957 a.a.

Protein Preferred Names

Protein Names

glutamyl aminopeptidase

AP-A

Recombinant ENPEP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72824	Aminopeptidase A Protein, Human (sf9, His)	Q07075 (R41-G957)	≥95%

Related Diseases

Diseases

Alias

Choriocarcinoma

Chorioepithelioma

Retinitis Pigmentosa 71

RP71	Retinitis Pigmentosa, Type 71

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Crimean-Congo Hemorrhagic Fever

Crimean Hemorrhagic Fever	Cchf
Congo Hemorrhagic Fever	Hemorrhagic Fever, Crimean
Chf Congo Virus	Congo-Crimean Hemorrhagic Fever
Congo Fever	Hemorrhagic Fever Crimean-Congo
Cchf - [Crimean-Congo Haemorrhagic Fever]	Kara Mikh Typhoid Fever
Xīnjiāng Haemorrhagic Fever

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04386	ENPEP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ENPEP	VGNC	VGNC:72221
Mus musculus	ENPEP	MGD	MGI:106645
Rattus norvegicus	ENPEP	RGD	RGD:621228
Felis catus	ENPEP	VGNC	VGNC:61871
Canis familiaris	ENPEP	VGNC	VGNC:40373
Bos taurus	ENPEP	VGNC	VGNC:28503
Others	ENPEP	NCBI

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