ADAM32 - ADAM metallopeptidase domain 32 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 203102

About ADAM32

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:39,107,529-39,284,917 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 362 orthologues and 20 paralogues. Restricted expression toward testis (RPKM 20.2).

Summary

This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of Other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

ADAM32 Products (2)

mRNA Protein Name
NM_001313994.1 NP_001300923.1 disintegrin and metalloproteinase domain-containing protein 32 isoform 2
NM_145004.7 NP_659441.4 disintegrin and metalloproteinase domain-containing protein 32 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM32 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (27 - 144)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (187 - 383)

Disintegrin

Disintegrin: Disintegrin (400 - 475)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (479 - 595)

  • 0
  • 200
  • 400
  • 600
  • 787 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 32

  • a disintegrin and metalloprotease domain 32

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00283 ADAM32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19049 Adam32 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25539 Adam32 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADAM32 MGD MGI:2653822
Canis familiaris ADAM32 VGNC VGNC:37584
Bos taurus ADAM32 VGNC VGNC:25610
Rattus norvegicus ADAM32 RGD RGD:735114
Others ADAM32 NCBI