NRK - Nik related kinase Gene

Homo sapiens

Also known as NESK

Gene ID: 203447 | Gene type: protein coding

About NRK

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:105,821,786-105,958,610 (from NCBI)

This gene has 4 transcripts (splice variants), 96 orthologues and 35 paralogues. Biased expression in ovary (RPKM 15.5), placenta (RPKM 15.0) and 8 other tissues.

Summary

The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]

NRK Products(1)

mRNA	Protein	Name
NM_198465.4	NP_940867.2	nik-related protein kinase

NRK Protein Structure

Pkinase

CNH

0
300
600
900
1200
1582 a.a.

Protein Preferred Names

Protein Names

nik-related protein kinase

Related Diseases

Diseases

Alias

Hypermobility Syndrome

Benign Joint Hypermobility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146434	TGFβ-IN-2	Inhibitor	/	Unkown
HY-147716	CDK8-IN-6	Inhibitor	/	Unkown
HY-147717	CDK8-IN-7	Inhibitor	/	Unkown
HY-RS09574	NRK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NRK	VGNC	VGNC:97537
Rattus norvegicus	NRK	RGD	RGD:1566163
Canis familiaris	NRK	VGNC	VGNC:43971
Mus musculus	NRK	MGD	MGI:1351326
Macaca mulatta	NRK	VGNC	VGNC:81488

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