Six5 - sine oculis-related homeobox 5 Gene

Also Known as Dmahp; MDMAHP; TrexBF

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20475

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of skeletal muscle satellite cell proliferation; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within lens development in camera-type eye; negative regulation of cell population proliferation; and spermatid development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Orthologous to human SIX5 (SIX homeobox 5). [provided by Alliance of Genome Resources, Apr 2022]

Six5 Products (1)

mRNA Protein Name
NM_011383.1 NP_035513.1 homeobox protein SIX5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14966291 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20696153 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8814301 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8814301 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of Leydig cell proliferation IMP
IMP: Inferred from mutant phenotype
15163633 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15163633 MGI
acts upstream of or within lens development in camera-type eye IMP
IMP: Inferred from mutant phenotype
10802667 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20696153 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15163633 MGI
involved in negative regulation of skeletal muscle satellite cell proliferation IMP
IMP: Inferred from mutant phenotype
20696153 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20696153 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
15163633 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8814301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein SIX5

  • DM locus-associated homeodomain protein homolog

  • sine oculis homeobox homolog 5

  • sine oculis-related homeobox 5 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12962 SIX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21435 Six5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27953 Six5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Six5 NCBI NCBI:147912