Smpd1 - sphingomyelin phosphodiesterase 1, acid lysosomal Gene

Also Known as ASM; aSMase; A-SMase; Zn-SMase

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20597

Summary

Enables acid sphingomyelin phosphodiesterase activity and zinc ion binding activity. Involved in ceramide biosynthetic process; positive regulation of apoptotic process; and response to ionizing radiation. Acts upstream of or within ceramide metabolic process; Cholesterol metabolic process; and sphingomyelin catabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease; Niemann-Pick disease type A; and Niemann-Pick disease type B. Orthologous to human SMPD1 (sphingomyelin phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]

Smpd1 Products (2)

mRNA Protein Name
NM_011421.2 NP_035551.1 sphingomyelin phosphodiesterase precursor
NM_011421.2 NP_035551.1 sphingomyelin phosphodiesterase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acid sphingomyelin phosphodiesterase activity IDA
IDA: Inferred from direct assay
8702487 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
8702487 MGI
Biological Process GO Annotation Evidence References Source
involved in ceramide biosynthetic process IDA
IDA: Inferred from direct assay
35705808 MGI
involved in ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
8706124 MGI
acts upstream of or within ceramide metabolic process IMP
IMP: Inferred from mutant phenotype
23046545 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
22383528 MGI
involved in plasma membrane repair IDA
IDA: Inferred from direct assay
35705808 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
8706124 MGI
involved in response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
8706124 MGI
acts upstream of or within sphingomyelin catabolic process IMP
IMP: Inferred from mutant phenotype
23973266 MGI
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IDA
IDA: Inferred from direct assay
35705808 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
8702487 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingomyelin phosphodiesterase

  • acid sphingomyelinase

Recombinant Smpd1 Proteins

Cat. No. Product Name Accession Purity
HY-P76134 SMPD1 Protein, Mouse (sf9, His) Q04519 (L45-L626) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17994 Smpd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-134505 Avicin G Inhibitor / Unkown
HY-186165 KARI 101 / Unkown
HY-RS13447 SMPD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24465 Smpd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smpd1 NCBI NCBI:6609