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Sox4 - SRY (sex determining region Y)-box 4 Gene

Also Known as Sox-4

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20677

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and miRNA binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cell communication. Acts upstream of or within endocrine pancreas development; hematopoietic stem cell homeostasis; and somatic stem cell population maintenance. Located in nucleus. Part of transcription regulator complex. Is active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome and urinary bladder Cancer. Orthologous to human SOX4 (SRY-box transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Sox4 Products (2)

mRNA	Protein	Name
NM_009238.3	NP_033264.2	transcription factor SOX-4
NM_009238.3	NP_033264.2	transcription factor SOX-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18403418	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18505825	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	21527504	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22344693	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20596238	MGI
enables miRNA binding	IDA IDA: Inferred from direct assay	26802803	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17875931	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18505825	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	9174623	MGI
involved in ascending aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	16109771	MGI
involved in atrial septum primum morphogenesis	IMP IMP: Inferred from mutant phenotype	16109771	MGI
involved in cardiac right ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	16109771	MGI
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	18477811	MGI
acts upstream of or within endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	16306355	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	31281513	MGI
involved in glial cell development	IMP IMP: Inferred from mutant phenotype	20147379	MGI
involved in glial cell proliferation	IMP IMP: Inferred from mutant phenotype	20147379	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	18477811	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	8614465	MGI
acts upstream of or within hematopoietic stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	26880577	MGI
involved in kidney morphogenesis	IMP IMP: Inferred from mutant phenotype	16109771	MGI
involved in mesenchyme development	IMP IMP: Inferred from mutant phenotype	20596238	MGI
involved in mitral valve morphogenesis	IMP IMP: Inferred from mutant phenotype	16109771	MGI
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	20596238	MGI
involved in neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	20646169	MGI
involved in noradrenergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	20147379	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20596238	MGI
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17875931	MGI
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17875931	MGI
involved in positive regulation of gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	23562159	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18477811	MGI
involved in positive regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	26291311	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18403418	MGI
involved in pro-B cell differentiation	IMP IMP: Inferred from mutant phenotype	8614465	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17875931	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23562159	MGI
acts upstream of or within somatic stem cell population maintenance	IDA IDA: Inferred from direct assay	19379700	MGI
involved in spinal cord development	IMP IMP: Inferred from mutant phenotype	20646169	MGI
involved in sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	20147379	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	16109771	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	26802803	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15645444	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	22344693	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor SOX-4	SRY-box containing gene 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13595	SOX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174601	Human IL5RA mRNA		/	Unkown
HY-RS17375	Sox4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23829	Sox4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox4	NCBI	NCBI:6659