Sox6 - SRY (sex determining region Y)-box 6 Gene

Also Known as SOX-LZ

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20679

Summary

This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Sox6 Products (6)

mRNA Protein Name
NM_001025559.3 NP_001020730.1 transcription factor SOX-6 isoform 2
NM_001025560.2 NP_001020731.1 transcription factor SOX-6 isoform 3
NM_001277326.1 NP_001264255.1 transcription factor SOX-6 isoform 1
NM_001277327.1 NP_001264256.1 transcription factor SOX-6 isoform 2
NM_001277328.1 NP_001264257.1 transcription factor SOX-6 isoform 4
NM_011445.4 NP_035575.1 transcription factor SOX-6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12446692 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12446692 MGI
enables DNA-binding transcription factor activity IGI
IGI: Inferred from genetic interaction
9755172 MGI
enables DNA-binding transcription repressor activity IDA
IDA: Inferred from direct assay
26525805 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
16462943 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
27880909 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
16462943 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9755172 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16462943 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
17084361 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac muscle cell differentiation IDA
IDA: Inferred from direct assay
14530442 MGI
involved in cartilage condensation IMP
IMP: Inferred from mutant phenotype
11702786 MGI
involved in cartilage development IDA
IDA: Inferred from direct assay
15529345 MGI
acts upstream of or within cartilage development IGI
IGI: Inferred from genetic interaction
15634692 MGI
involved in cartilage development IMP
IMP: Inferred from mutant phenotype
26150426 MGI
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
15634692 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
16462943 MGI
involved in chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
11702786 MGI
acts upstream of or within erythrocyte development IMP
IMP: Inferred from mutant phenotype
16462943 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
20711497 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
27880909 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
16462943 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17084361 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17084361 MGI
acts upstream of or within negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16462943 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16462943 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16462943 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16462943 MGI
acts upstream of or within oligodendrocyte cell fate specification IMP
IMP: Inferred from mutant phenotype
17084361 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17084361 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17084361 MGI
involved in positive regulation of chondrocyte differentiation IDA
IDA: Inferred from direct assay
20940257 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
9755172 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
16462943 MGI
involved in regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
27880909 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12446692 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20711497 MGI
involved in spinal cord oligodendrocyte cell differentiation IMP
IMP: Inferred from mutant phenotype
26525805 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9755172 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor SOX-6

  • SRY-box containing gene 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13597 SOX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20338 Sox6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26846 Sox6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sox6 NCBI NCBI:55553