Spta1 - spectrin alpha, erythrocytic 1 Gene

Also Known as ha; ihj; sph; nmf4; Spna1; Spna-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20739

Summary

Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including lymphocyte homeostasis; porphyrin-containing compound biosynthetic process; and positive regulation of T cell proliferation. Located in cuticular plate; membrane; and spectrin-associated Cytoskeleton. Part of spectrin. Is expressed in liver; liver left lobe; and liver right lobe. Used to study hereditary spherocytosis type 1; hereditary spherocytosis type 3; and sickle cell anemia. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 3. Orthologous to human SPTA1 (spectrin alpha, erythrocytic 1). [provided by Alliance of Genome Resources, Apr 2022]

Spta1 Products (1)

mRNA Protein Name
NM_011465.4 NP_035595.2 spectrin alpha chain, erythrocytic 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20585040 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
8195289 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
6841965 MGI
acts upstream of or within lymphocyte homeostasis IMP
IMP: Inferred from mutant phenotype
1934076 MGI
acts upstream of or within plasma membrane organization IMP
IMP: Inferred from mutant phenotype
6841965 MGI
acts upstream of or within porphyrin-containing compound biosynthetic process IMP
IMP: Inferred from mutant phenotype
658175 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
7684329 MGI
acts upstream of or within positive regulation of protein binding IGI
IGI: Inferred from genetic interaction
20585040 MGI
acts upstream of or within regulation of cell shape IMP
IMP: Inferred from mutant phenotype
8195289 MGI
Cellular Component GO Annotation Evidence References Source
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
18723693 MGI
located in cuticular plate IDA
IDA: Inferred from direct assay
20016102 MGI
located in membrane IDA
IDA: Inferred from direct assay
18723693 MGI
part of spectrin IMP
IMP: Inferred from mutant phenotype
6234993 MGI
located in spectrin-associated cytoskeleton IMP
IMP: Inferred from mutant phenotype
6234993 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spectrin alpha chain, erythrocytic 1

  • alpha-spectrin 1, erythroid

  • erythroid alpha-spectrin

  • hemolytic anemia

  • neuroscience mutagenesis facility, 4

  • spectrin alpha 1

  • spectrin alpha chain, erythrocyte

  • spherocytosis

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13729 SPTA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22829 Spta1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spta1 NCBI NCBI:6708