Abcc9 - ATP-binding cassette, sub-family C (CFTR/MRP), member 9 Gene

Also Known as Sur2; SUR2A; SUR2B

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20928

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Abcc9 Products (8)

mRNA Protein Name
NM_001044720.2 NP_001038185.1 ATP-binding cassette sub-family C member 9 isoform d
NM_001310143.2 NP_001297072.1 ATP-binding cassette sub-family C member 9 isoform e
NM_001410414.1 NP_001397343.1 ATP-binding cassette sub-family C member 9 isoform f
NM_001410415.1 NP_001397344.1 ATP-binding cassette sub-family C member 9 isoform g
NM_001410416.1 NP_001397345.1 ATP-binding cassette sub-family C member 9 isoform h
NM_011511.3 NP_035641.1 ATP-binding cassette sub-family C member 9 isoform a
NM_021041.3 NP_066378.1 ATP-binding cassette sub-family C member 9 isoform b
NM_021042.3 NP_066379.2 ATP-binding cassette sub-family C member 9 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to potassium channel activity IMP
IMP: Inferred from mutant phenotype
20656890 MGI
enables potassium channel activity IMP
IMP: Inferred from mutant phenotype
16456098 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18001767 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
11934987 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ATP metabolic process IDA
IDA: Inferred from direct assay
20123112 MGI
acts upstream of or within MAPK cascade IMP
IMP: Inferred from mutant phenotype
11934987 MGI
acts upstream of or within action potential IDA
IDA: Inferred from direct assay
24037327 MGI
acts upstream of or within action potential IMP
IMP: Inferred from mutant phenotype
24037327 MGI
acts upstream of or within blood circulation IMP
IMP: Inferred from mutant phenotype
24936167 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
30089727 MGI
acts upstream of or within blood vessel diameter maintenance IMP
IMP: Inferred from mutant phenotype
19675276 MGI
acts upstream of or within positive effect cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
31575858 MGI
acts upstream of or within cellular respiration IMP
IMP: Inferred from mutant phenotype
24648545 MGI
acts upstream of or within cellular response to ATP IDA
IDA: Inferred from direct assay
24037327 MGI
acts upstream of or within cellular response to ATP IMP
IMP: Inferred from mutant phenotype
20935152 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
24037327 MGI
acts upstream of or within cellular response to calcium ion IMP
IMP: Inferred from mutant phenotype
20935152 MGI
acts upstream of or within cellular response to chemical stress IDA
IDA: Inferred from direct assay
20123112 MGI
acts upstream of or within cellular response to potassium ion IMP
IMP: Inferred from mutant phenotype
20935152 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
24037327 MGI
acts upstream of or within cellular response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
24037327 MGI
acts upstream of or within circulatory system development IMP
IMP: Inferred from mutant phenotype
30089727 MGI
acts upstream of or within coronary vasculature development IGI
IGI: Inferred from genetic interaction
31821173 MGI
acts upstream of or within cytokine production IGI
IGI: Inferred from genetic interaction
19166858 MGI
acts upstream of or within fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
24648545 MGI
acts upstream of or within fibroblast proliferation IGI
IGI: Inferred from genetic interaction
19166858 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
11934987 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
19675276 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
31821173 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
30089727 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
24648545 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
20123112 MGI
acts upstream of or within negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
31575858 MGI
acts upstream of or within oxygen metabolic process IMP
IMP: Inferred from mutant phenotype
24648545 MGI
acts upstream of or within potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
20123112 MGI
acts upstream of or within reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
20935152 MGI
acts upstream of or within regulation of blood pressure IGI
IGI: Inferred from genetic interaction
31821173 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
19675276 MGI
acts upstream of or within regulation of cation channel activity IGI
IGI: Inferred from genetic interaction
31821173 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
20935152 MGI
acts upstream of or within regulation of potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
18001767 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11934987 MGI
acts upstream of or within regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IMP
IMP: Inferred from mutant phenotype
31575858 MGI
acts upstream of or within response to ATP IMP
IMP: Inferred from mutant phenotype
30089727 MGI
acts upstream of or within response to activity IMP
IMP: Inferred from mutant phenotype
19675276 MGI
acts upstream of or within response to decreased oxygen levels IMP
IMP: Inferred from mutant phenotype
20935152 MGI
acts upstream of or within response to estrogen IDA
IDA: Inferred from direct assay
24936167 MGI
acts upstream of or within response to estrogen IMP
IMP: Inferred from mutant phenotype
24936167 MGI
acts upstream of or within response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
24648545 MGI
acts upstream of or within response to hydrogen sulfide IMP
IMP: Inferred from mutant phenotype
21421823 MGI
acts upstream of or within response to hypoxia IDA
IDA: Inferred from direct assay
20123112 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
20935152 MGI
acts upstream of or within response to oxygen levels IMP
IMP: Inferred from mutant phenotype
24936167 MGI
acts upstream of or within response to peptide IMP
IMP: Inferred from mutant phenotype
11934987 MGI
acts upstream of or within response to potassium ion IMP
IMP: Inferred from mutant phenotype
18001767 MGI
acts upstream of or within response to stress IMP
IMP: Inferred from mutant phenotype
19675276 MGI
acts upstream of or within response to xenobiotic stimulus IGI
IGI: Inferred from genetic interaction
19166858 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
11934987 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
19675276 MGI
acts upstream of or within vascular process in circulatory system IMP
IMP: Inferred from mutant phenotype
16456098 MGI
acts upstream of or within vasodilation IMP
IMP: Inferred from mutant phenotype
21421823 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
18434629 MGI
is active in mitochondrion IDA
IDA: Inferred from direct assay
19797704 MGI
is active in mitochondrion IMP
IMP: Inferred from mutant phenotype
19797704 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
24037327 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16085792 MGI
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
11934987 MGI
is active in sarcolemma IDA
IDA: Inferred from direct assay
18001767 MGI
located in sarcomere IDA
IDA: Inferred from direct assay
16085792 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 9

  • ATP-binding cassette transporter sub-family C member 9

  • sulfonylurea receptor 2

  • sulfonylurea-binding protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00067 ABCC9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22364 Abcc9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28888 Abcc9 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcc9 NCBI NCBI:10060