Syt1 - synaptotagmin I Gene

Also Known as SytI; G630098F17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20979

Summary

Enables several functions, including calcium ion sensor activity; calcium-dependent phospholipid binding activity; and syntaxin-1 binding activity. Involved in modulation of chemical synaptic transmission; regulation of dopamine secretion; and synaptic vesicle exocytosis. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; spontaneous neurotransmitter secretion; and synchronous neurotransmitter secretion. Located in several cellular components, including glutamatergic synapse; presynaptic membrane; and secretory vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Apr 2022]

Syt1 Products (8)

mRNA Protein Name
NM_001252341.1 NP_001239270.1 synaptotagmin-1 isoform 1
NM_001252342.1 NP_001239271.1 synaptotagmin-1 isoform 2
NM_001358501.1 NP_001345430.1 synaptotagmin-1 isoform 2
NM_001358502.1 NP_001345431.1 synaptotagmin-1 isoform 1
NM_001358503.1 NP_001345432.1 synaptotagmin-1 isoform 1
NM_001358504.1 NP_001345433.1 synaptotagmin-1 isoform 2
NM_001358506.1 NP_001345435.1 synaptotagmin-1 isoform 2
NM_009306.3 NP_033332.1 synaptotagmin-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
15197251 MGI
enables calcium ion sensor activity IDA
IDA: Inferred from direct assay
21521611 MGI
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
8626542 MGI
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
15774481 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14726597 MGI
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
18703708 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter IMP
IMP: Inferred from mutant phenotype
21521611 MGI
involved in calcium-dependent activation of synaptic vesicle fusion IDA
IDA: Inferred from direct assay
7954835 MGI
involved in calcium-dependent activation of synaptic vesicle fusion IEP
IEP: Inferred from expression pattern
7954835 MGI
involved in calcium-dependent activation of synaptic vesicle fusion IMP
IMP: Inferred from mutant phenotype
7954835 MGI
involved in fast, calcium ion-dependent exocytosis of neurotransmitter IDA
IDA: Inferred from direct assay
12526776 MGI
involved in fast, calcium ion-dependent exocytosis of neurotransmitter IMP
IMP: Inferred from mutant phenotype
7954835 MGI
acts upstream of or within neurotransmitter secretion IDA
IDA: Inferred from direct assay
15197251 MGI
involved in positive regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
IMP: Inferred from mutant phenotype
11242035 MGI
involved in positive regulation of synaptic transmission IMP
IMP: Inferred from mutant phenotype
7954835 MGI
involved in regulation of calcium ion-dependent exocytosis IMP
IMP: Inferred from mutant phenotype
11562488 MGI
involved in regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
21576241 MGI
involved in regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
12526776 MGI
acts upstream of or within spontaneous neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
21521611 MGI
acts upstream of or within synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
21040848 MGI
acts upstream of or within synchronous neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
21521611 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
14622145 MGI
located in axon IDA
IDA: Inferred from direct assay
21576241 MGI
located in dense core granule IDA
IDA: Inferred from direct assay
18468511 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
7954835 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
7954835 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
7954835 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
14622145 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
15197251 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
12145198 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
16407767 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
15071120 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-1

  • p65

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182539 DD04107 Modulator / Unkown
HY-P5043 α-Synuclein (67-78) (human) / Unkown
HY-RS14106 SYT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22338 Syt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28860 Syt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syt1 NCBI NCBI:6857