Tacr1 - tachykinin receptor 1 Gene

Also Known as Spr; Nk1r; Tac1r

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21336

About Tacr1

Chromosome 6: 82,379,315-82,537,085 forward strand.GRCm39:CM000999.3

This gene has 3 transcripts (splice variants), 270 orthologues, 55 paralogues and is associated with 34 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes the receptor for the tachykinin, substance P, also referred to as neurokinin 1. This gene belongs to a gene family of tachykinin receptors which are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This receptor has been associated with nitric oxide formation, and it has been localized to cholinergic and nitrergic neurons as well as on smooth muscle cells. [provided by RefSeq, Mar 2010]

Tacr1 Products (1)

mRNA Protein Name
NM_009313.5 NP_033339.2 substance-P receptor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in regulation of uterine smooth muscle contraction IDA
IDA: Inferred from direct assay
15647454 MGI
acts upstream of or within response to pain IMP
IMP: Inferred from mutant phenotype
11805341 MGI
Cellular Component GO Annotation Evidence References Source
located in cell periphery IDA
IDA: Inferred from direct assay
12383972 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tacr1 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (32 - 315)

7tm_GPCRs

7tm_GPCRs: cd14964 (34 - 58)

7tm_GPCRs

7tm_GPCRs: cd14964 (67 - 89)

7tm_GPCRs

7tm_GPCRs: cd14964 (105 - 127)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (193 - 216)

7tm_GPCRs

7tm_GPCRs: cd14964 (246 - 268)

7tm_GPCRs

7tm_GPCRs: cd14964 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
Protein Preferred Names Protein Names

substance-P receptor

  • Nk1 receptor

  • neurokinin receptor 1

  • substance P receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14143 TACR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14144 Tacr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14145 Tacr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tacr1 NCBI NCBI:6869