Slc6a6 - solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Gene

Also Known as Taut

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21366

Summary

Enables beta-alanine transmembrane transporter activity and taurine transmembrane transporter activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within beta-alanine transport and taurine transport. Located in GABA-ergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including cardiovascular system; central nervous system; placenta; retina; and tooth. Used to study retinitis pigmentosa. Orthologous to human SLC6A6 (solute carrier family 6 member 6). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a6 Products (8)

mRNA Protein Name
NM_001410446.1 NP_001397375.1 sodium- and chloride-dependent taurine transporter isoform a
NM_001410447.1 NP_001397376.1 sodium- and chloride-dependent taurine transporter isoform a
NM_001410448.1 NP_001397377.1 sodium- and chloride-dependent taurine transporter isoform b
NM_001410449.1 NP_001397378.1 sodium- and chloride-dependent taurine transporter isoform c precursor
NM_001410450.1 NP_001397379.1 sodium- and chloride-dependent taurine transporter isoform d precursor
NM_001410451.1 NP_001397380.1 sodium- and chloride-dependent taurine transporter isoform e
NM_001410452.1 NP_001397381.1 sodium- and chloride-dependent taurine transporter isoform e
NM_009320.5 NP_033346.2 sodium- and chloride-dependent taurine transporter isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amino acid:sodium symporter activity IDA
IDA: Inferred from direct assay
1465453 MGI
enables gamma-aminobutyric acid:sodium:chloride symporter activity IDA
IDA: Inferred from direct assay
30270321 MGI
enables taurine transmembrane transporter activity IDA
IDA: Inferred from direct assay
1465453 MGI
enables taurine:sodium symporter activity IDA
IDA: Inferred from direct assay
1465453 MGI
Biological Process GO Annotation Evidence References Source
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
12824447 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12824447 MGI
acts upstream of or within taurine transmembrane transport IDA
IDA: Inferred from direct assay
1465453 MGI
acts upstream of or within taurine transmembrane transport IMP
IMP: Inferred from mutant phenotype
11772953 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
12824447 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
12824447 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
17962336 MGI
is active in postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
17962336 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium- and chloride-dependent taurine transporter

  • solute carrier family 6 member 6

  • taurine/beta-alanine transporter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179581 SLC6A19-IN-4 Inhibitor 99.55% Unkown
HY-RS13317 SLC6A6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16229 Slc6a6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25565 Slc6a6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a6 NCBI NCBI:6533