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Tbx3 - T-box 3 Gene

Also Known as D5Ertd189e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21386

Summary

Enables DNA-binding transcription factor activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in atrioventricular canal morphogenesis. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study ulnar-mammary syndrome. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome. Orthologous to human TBX3 (T-box transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tbx3 Products (2)

mRNA	Protein	Name
NM_011535.3	NP_035665.2	T-box transcription factor TBX3 isoform 1
NM_198052.2	NP_932169.1	T-box transcription factor TBX3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17473172	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27720610	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	22164283	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	27046536	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17473172	MGI
acts upstream of or within atrioventricular bundle cell differentiation	IMP IMP: Inferred from mutant phenotype	18467625	MGI
involved in atrioventricular canal development	IGI IGI: Inferred from genetic interaction	22130515	MGI
involved in atrioventricular canal morphogenesis	IGI IGI: Inferred from genetic interaction	22130515	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	12668638	MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	16222716	MGI
acts upstream of or within cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	17234970	MGI
acts upstream of or within cardiac muscle cell fate commitment	IMP IMP: Inferred from mutant phenotype	18467625	MGI
acts upstream of or within cellular senescence	IDA IDA: Inferred from direct assay	11748239	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	23844108	MGI
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	27046536	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	23844108	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	23844108	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	17460765	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	17473172	MGI
acts upstream of hepatoblast differentiation	IMP IMP: Inferred from mutant phenotype	18356246	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17473172	MGI
involved in inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	33795231	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	12668638	MGI
involved in limb morphogenesis	IMP IMP: Inferred from mutant phenotype	27046536	MGI
acts upstream of or within limbic system development	IMP IMP: Inferred from mutant phenotype	17473172	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	12668638	MGI
acts upstream of or within mammary placode formation	IDA IDA: Inferred from direct assay	17071745	MGI
acts upstream of or within mammary placode formation	IGI IGI: Inferred from genetic interaction	16222716	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11748239	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17473172	MGI
acts upstream of or within negative regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	18356246	MGI
acts upstream of or within negative regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	18356246	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	27720610	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	18723448	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17473172	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18356246	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17460765	MGI
involved in regulation of protein complex stability	IMP IMP: Inferred from mutant phenotype	27046536	MGI
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	27046536	MGI
acts upstream of or within roof of mouth development	IGI IGI: Inferred from genetic interaction	19769959	MGI
involved in semicircular canal morphogenesis	IMP IMP: Inferred from mutant phenotype	33795231	MGI
acts upstream of or within sinoatrial node cell development	IMP IMP: Inferred from mutant phenotype	19096026	MGI
acts upstream of or within smooth muscle cell differentiation	IGI IGI: Inferred from genetic interaction	30478225	MGI
acts upstream of or within specification of animal organ position	IDA IDA: Inferred from direct assay	17071745	MGI
acts upstream of or within stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	18356246	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18356246	MGI
acts upstream of or within ureteric peristalsis	IGI IGI: Inferred from genetic interaction	30478225	MGI
acts upstream of or within ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	18467625	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cilium	IDA IDA: Inferred from direct assay	27046536	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18534921	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	18285513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
T-box transcription factor TBX3	T-box protein 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14279	TBX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20344	Tbx3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26853	Tbx3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbx3	NCBI	NCBI:6926