Tbx6 - T-box 6 Gene

Also Known as rv

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21389

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including negative regulation of neuron maturation; regulation of gene expression; and somite rostral/caudal axis specification. Located in chromatin and nucleus. Is expressed in several structures, including 4-cell stage embryo; embryo ectoderm; embryo mesenchyme; genitourinary system; and primitive streak. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human TBX6 (T-box transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]

Tbx6 Products (1)

mRNA	Protein	Name
NM_011538.2	NP_035668.2	T-box transcription factor TBX6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15986483	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	22164283	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	9490412	MGI
acts upstream of or within mesodermal cell fate specification	IMP IMP: Inferred from mutant phenotype	9490412	MGI
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	22164283	MGI
acts upstream of or within negative regulation of neuron maturation	IGI IGI: Inferred from genetic interaction	23015435	MGI
acts upstream of or within negative regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	23015435	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22164283	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21750544	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within somite rostral/caudal axis specification	IDA IDA: Inferred from direct assay	20346937	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	22164283	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15986483	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
T-box transcription factor TBX6	T-box protein 6 rib-vertebrae

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14282	TBX6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22340	Tbx6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28862	Tbx6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbx6	NCBI	NCBI:6911