Tcf12 - transcription factor 12 Gene

Also Known as HEB; ME1; REB; ALF1; HTF4; HTF-4; HEBAlt; bHLHb20; A130037E08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21406

Summary

Enables E-box binding activity and protein heterodimerization activity. Involved in positive regulation of neuron differentiation. Acts upstream of or within positive regulation of gene expression and positive regulation of transcription, DNA-templated. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in craniosynostosis. Orthologous to human TCF12 (transcription factor 12). [provided by Alliance of Genome Resources, Apr 2022]

Tcf12 Products (5)

mRNA Protein Name
NM_001253862.1 NP_001240791.1 transcription factor 12 isoform 2
NM_001253863.1 NP_001240792.1 transcription factor 12 isoform 3
NM_001253864.1 NP_001240793.1 transcription factor 12 isoform 4
NM_001253865.1 NP_001240794.1 transcription factor 12 isoform 5
NM_011544.3 NP_035674.2 transcription factor 12 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
1321336 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
18214987 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
1922066 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
18214987 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of gene expression IMP
IMP: Inferred from mutant phenotype
18958875 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
1321336 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18958875 MGI
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
18214987 MGI
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15351717 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor 12

  • DNA-binding protein HTF4

  • E-box-binding protein

  • TCF-12

  • class A helix-loop-helix transcription factor ME1

  • transcription factor HTF-4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14299 TCF12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21063 Tcf12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27580 Tcf12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tcf12 NCBI NCBI:6938