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Tfap2a - transcription factor AP-2, alpha Gene

Also Known as Ap2; AP-2; Ap2tf; Tcfap2a; AP2alpha; Ap-2 (a)

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21418

Summary

This gene is a member of the activator protein 2 (AP-2) transcription factor family. The protein encoded by this gene can act as both an activator and repressor of gene transcription, and plays an important role in early embryogenesis, specifically in cranial development. This protein forms both homodimers and heterodimers, and binds to a GC-rich consensus sequence found in some promoters and enhancers. Disruption of this gene causes perinatal death, with neural tube, craniofacial, and limb mesenchyme defects. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Sep 2014]

Tfap2a Products (3)

mRNA	Protein	Name
NM_001122948.2	NP_001116420.1	transcription factor AP-2-alpha isoform 3
NM_001301674.2	NP_001288603.2	transcription factor AP-2-alpha isoform 1
NM_011547.5	NP_035677.3	transcription factor AP-2-alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7555706	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11522791	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16449191	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10068641	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9858544	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15475956	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19943855	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11522791	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	21829553	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	21829553	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior neuropore closure	IMP IMP: Inferred from mutant phenotype	8622765	MGI
acts upstream of or within basement membrane organization	IMP IMP: Inferred from mutant phenotype	16186342	MGI
involved in bone morphogenesis	IMP IMP: Inferred from mutant phenotype	8622766	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16449191	MGI
acts upstream of or within cornea development in camera-type eye	IMP IMP: Inferred from mutant phenotype	16186342	MGI
acts upstream of or within embryonic body morphogenesis	IMP IMP: Inferred from mutant phenotype	15013802	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	9811866	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	8622765	MGI
involved in embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	8622766	MGI
involved in embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	9811866	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	17984226	MGI
acts upstream of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16449191	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: Inferred from mutant phenotype	16449191	MGI
involved in eyelid development in camera-type eye	IMP IMP: Inferred from mutant phenotype	9811866	MGI
acts upstream of or within face morphogenesis	IMP IMP: Inferred from mutant phenotype	9811866	MGI
acts upstream of fibroblast migration	IMP IMP: Inferred from mutant phenotype	19463168	MGI
acts upstream of or within forebrain neuron development	IMP IMP: Inferred from mutant phenotype	10803593	MGI
acts upstream of or within forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	9811866	MGI
acts upstream of or within keratinocyte development	IGI IGI: Inferred from genetic interaction	18824566	MGI
acts upstream of or within lens induction in camera-type eye	IMP IMP: Inferred from mutant phenotype	10571739	MGI
acts upstream of or within lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	9918694	MGI
involved in metanephric nephron development	IEP IEP: Inferred from expression pattern	7555706	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16449191	MGI
acts upstream of or within negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16449191	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	21539825	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21829553	MGI
involved in nervous system development	IEP IEP: Inferred from expression pattern	7555706	MGI
acts upstream of or within neural crest cell development	IMP IMP: Inferred from mutant phenotype	8622766	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	8622766	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	21539825	MGI
involved in oculomotor nerve formation	IMP IMP: Inferred from mutant phenotype	8622766	MGI
involved in optic cup structural organization	IMP IMP: Inferred from mutant phenotype	20150232	MGI
involved in optic vesicle morphogenesis	IMP IMP: Inferred from mutant phenotype	20150232	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	11744375	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15475956	MGI
acts upstream of or within positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	19463168	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	15475956	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7555706	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9858544	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11522791	MGI
acts upstream of or within regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	10842061	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15475956	MGI
involved in sensory organ development	IEP IEP: Inferred from expression pattern	7555706	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	8622765	MGI
involved in skin development	IEP IEP: Inferred from expression pattern	7555706	MGI
acts upstream of or within skin development	IGI IGI: Inferred from genetic interaction	18824566	MGI
acts upstream of or within sympathetic nervous system development	IGI IGI: Inferred from genetic interaction	21539825	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11694877	MGI
involved in trigeminal nerve development	IMP IMP: Inferred from mutant phenotype	8622766	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	26437238	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10842061	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor AP-2-alpha	activating enhancer-binding protein 2 alpha activator protein 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14408	TFAP2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19271	Tfap2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25760	Tfap2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tfap2a	NCBI	NCBI:7020