Flcn - folliculin Gene

Also Known as Bhd; FLCL; B430214A04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216805

Summary

Predicted to enable GTPase activator activity. Involved in several processes, including energy homeostasis; negative regulation of brown fat cell differentiation; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within with a positive effect on negative regulation of cell population proliferation. Acts upstream of or within several processes, including negative regulation of cell proliferation involved in kidney development; positive regulation of transforming growth factor beta receptor signaling pathway; and regulation of intracellular signal transduction. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule Cytoskeleton. Predicted to be active in cytosol. Predicted to colocalize with cell-cell contact zone and midbody. Is expressed in several structures, including embryo ectoderm; exocrine gland; extraembryonic component; limb bud; and optic cup. Used to study Birt-Hogg-Dube syndrome and nonpapillary renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin). [provided by Alliance of Genome Resources, Apr 2022]

Flcn Products (3)

mRNA Protein Name
NM_001271356.1 NP_001258285.1 folliculin
NM_001271357.1 NP_001258286.1 folliculin
NM_146018.2 NP_666130.1 folliculin

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23582324 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
18182616 MGI
acts upstream of TOR signaling IMP
IMP: Inferred from mutant phenotype
18182616 MGI
acts upstream of cell proliferation involved in kidney development IMP
IMP: Inferred from mutant phenotype
18182616 MGI
involved in cell-cell junction assembly IMP
IMP: Inferred from mutant phenotype
22965878 MGI
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
23150719 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18182616 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
21258407 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
21258407 MGI
acts upstream of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21258407 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
21209915 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
18182616 MGI
acts upstream of or within negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
18182616 MGI
involved in negative regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
27913603 MGI
acts upstream of or within positive effect negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
25775561 MGI
acts upstream of or within negative regulation of cell proliferation involved in kidney development IMP
IMP: Inferred from mutant phenotype
18182616 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
27151976 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18182616 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
19850877 MGI
involved in negative regulation of post-translational protein modification IMP
IMP: Inferred from mutant phenotype
21209915 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21209915 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
19850877 MGI
acts upstream of or within positive regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
19234517 MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21258407 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21258407 MGI
acts upstream of or within regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
19843504 MGI
acts upstream of or within regulation of pro-B cell differentiation IMP
IMP: Inferred from mutant phenotype
22709692 MGI
acts upstream of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21258407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

folliculin

  • birt-Hogg-Dube syndrome protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04974 FLCN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21342 Flcn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27861 Flcn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Flcn NCBI NCBI:201163