Thbs1 - thrombospondin 1 Gene

Also Known as TSP1; TSP-1; tbsp1; Thbs-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21825

Summary

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V Collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Thbs1 Products (2)

mRNA Protein Name
NM_001313914.1 NP_001300843.1 thrombospondin-1 isoform 2 precursor
NM_011580.4 NP_035710.2 thrombospondin-1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellular matrix binding IDA
IDA: Inferred from direct assay
18757743 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22682248 MGI
Biological Process GO Annotation Evidence References Source
involved in behavioral response to pain IMP
IMP: Inferred from mutant phenotype
22745497 MGI
acts upstream of or within blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
20026598 MGI
acts upstream of or within cellular response to nitric oxide IMP
IMP: Inferred from mutant phenotype
16150726 MGI
acts upstream of or within endocardial cushion development IGI
IGI: Inferred from genetic interaction
20026598 MGI
acts upstream of or within growth plate cartilage development IGI
IGI: Inferred from genetic interaction
18467703 MGI
acts upstream of or within growth plate cartilage development IMP
IMP: Inferred from mutant phenotype
18467703 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
15963261 MGI
acts upstream of or within monocyte aggregation IMP
IMP: Inferred from mutant phenotype
28228282 MGI
acts upstream of or within negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
12498716 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
16150726 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16150726 MGI
acts upstream of or within outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
20026598 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
18757743 MGI
involved in positive regulation of macrophage chemotaxis IMP
IMP: Inferred from mutant phenotype
18757424 MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9657149 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
22682248 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22682248 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
18285447 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
12498716 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
22682248 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thrombospondin-1

  • glycoprotein G

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14479 THBS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16903 Thbs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23345 Thbs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Thbs1 NCBI NCBI:7057