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Tjp1 - tight junction protein 1 Gene

Also Known as ZO1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21872

Summary

Enables connexin binding activity and protein domain specific binding activity. Involved in negative regulation of stress fiber assembly; positive regulation of sprouting angiogenesis; and protein localization to cell-cell junction. Acts upstream of or within blastocyst formation and sensory perception of sound. Located in several cellular components, including apicolateral plasma membrane; bicellular tight junction; and intercellular canaliculus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TJP1 (tight junction protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Tjp1 Products (2)

mRNA	Protein	Name
NM_001163574.1	NP_001157046.1	tight junction protein ZO-1 isoform 2
NM_009386.2	NP_033412.2	tight junction protein ZO-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables connexin binding	IPI IPI: Inferred from physical interaction	14699011	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10601346	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17666436	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in ameloblast differentiation	IMP IMP: Inferred from mutant phenotype	27015268	MGI
acts upstream of or within blastocyst formation	IMP IMP: Inferred from mutant phenotype	18423437	MGI
involved in negative regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	25753039	MGI
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	25753039	MGI
involved in protein localization to cell-cell junction	IMP IMP: Inferred from mutant phenotype	25753039	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	23979167	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	11731229	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	23434913	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21947081	MGI
located in apicolateral plasma membrane	IDA IDA: Inferred from direct assay	16520537	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	10395790	MGI
located in cell junction	IDA IDA: Inferred from direct assay	16427635	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	18423437	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16427635	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	18603586	MGI
located in intercellular canaliculus	IDA IDA: Inferred from direct assay	12068294	MGI
located in membrane	IDA IDA: Inferred from direct assay	15788452	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14685273	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12060405	MGI
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15492000	MGI
located in tight junction	IDA IDA: Inferred from direct assay	24588076	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tight junction protein ZO-1	zona occludens protein 1 zonula occludens protein 1

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10886	Zifogaptide	Modulator	98.97%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS20347	Tjp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14553	TJP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26856	Tjp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tjp1	NCBI	NCBI:7082