Rarb - retinoic acid receptor, beta Gene

Also Known as Hap; Nr1b2; A830025K23

Species: Mus musculus

Gene Type: protein coding
Gene ID: 218772

Summary

Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; regulation of apoptotic process; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in asbestos-related lung carcinoma; lung adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and syndromic microphthalmia 12. Orthologous to human RARB (retinoic acid receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Rarb Products (4)

mRNA Protein Name
NM_001289760.1 NP_001276689.1 retinoic acid receptor beta isoform beta3
NM_001289761.1 NP_001276690.1 retinoic acid receptor beta isoform beta1
NM_001289762.1 NP_001276691.1 retinoic acid receptor beta isoform beta4
NM_011243.2 NP_035373.1 retinoic acid receptor beta isoform beta2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
8152920 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 MGI
enables sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
7823919 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
7607067 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within embryonic eye morphogenesis IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within glandular epithelial cell development IGI
IGI: Inferred from genetic interaction
7607067 MGI
acts upstream of or within growth plate cartilage development IGI
IGI: Inferred from genetic interaction
19389355 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
19389355 MGI
acts upstream of or within negative regulation of cartilage development IMP
IMP: Inferred from mutant phenotype
10684250 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
10684250 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8152920 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
18443282 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within positive regulation of programmed cell death IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
7823919 MGI
acts upstream of programmed cell death IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
10075839 MGI
acts upstream of or within striatum development IMP
IMP: Inferred from mutant phenotype
18443282 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
12195422 MGI
acts upstream of or within ventricular cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
9428411 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinoic acid receptor beta

  • RAR-beta

  • nuclear receptor subfamily 1 group B member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11672 RARB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21414 Rarb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27933 Rarb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rarb NCBI NCBI:5915