Plscr1 - phospholipid scramblase 1 Gene

Also Known as Nor1; Tra1; Tra1a; Tra1b; Tras1; Tras2; MmTRA1a; MmTRA1b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22038

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of viral genome replication; phosphatidylserine biosynthetic process; and response to interferon-alpha. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Located in cytosol; nucleus; and plasma membrane. Is expressed in hindgut; midgut; renal calyx; and renal pelvis. Orthologous to human PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Apr 2022]

Plscr1 Products (2)

mRNA Protein Name
NM_001410453.1 NP_001397382.1 phospholipid scramblase 1
NM_011636.3 NP_035766.2 phospholipid scramblase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32110987 MGI
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IEP
IEP: Inferred from expression pattern
17590392 MGI
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
17590392 MGI
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17590392 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
15308695 MGI
involved in intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
15863367 MGI
acts upstream of or within myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
15328404 MGI
acts upstream of or within negative regulation of protein binding IDA
IDA: Inferred from direct assay
16611984 MGI
involved in negative regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
15308695 MGI
involved in phosphatidylserine biosynthetic process IDA
IDA: Inferred from direct assay
12509439 MGI
acts upstream of or within phosphatidylserine exposure on apoptotic cell surface IDA
IDA: Inferred from direct assay
12509439 MGI
involved in phosphatidylserine exposure on apoptotic cell surface IMP
IMP: Inferred from mutant phenotype
32110987 MGI
involved in plasma membrane phospholipid scrambling IDA
IDA: Inferred from direct assay
12509439 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
16611984 MGI
involved in positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
15308695 MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: Inferred from direct assay
12509439 MGI
involved in response to interferon-alpha IMP
IMP: Inferred from mutant phenotype
15308695 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
17590392 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17590392 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12509439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipid scramblase 1

  • PL scramblase 1

  • ca(2+)-dependent phospholipid scramblase 1

  • mg(2+)-dependent nuclease

  • transplantability-associated protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10741 PLSCR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18201 Plscr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24677 Plscr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plscr1 NCBI NCBI:5359